Anti-GRK6 Antibody | MyBioSource MBS820205 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-GRK6 Antibody

catalog :

MBS820205

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of GRK6 expression in Jurkat (A), BJAB (B), Ramos (C) whole cell lysates.

image 2 :

Immunohistochemical analysis of GRK6 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

product information

catalog number :

MBS820205

products type :

Antibody

products full name :

Anti-GRK6 Antibody

products short name :

[GRK6]

products name syn :

[GPRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6]

other names :

[G protein-coupled receptor kinase 6 isoform C; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6]

products gene name :

[GRK6]

other gene names :

[GRK6; GRK6; GPRK6; GPRK6]

uniprot entry name :

GRK6_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse, Rat

sequence length :

560

specificity :

Recognizes endogenous levels of GRK6 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

app notes :

WB (1/500 - 1/1000), IH (1/100 - 1/200), IP (1/10 - 1/100)

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Source: Rabbit

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GRK6. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to GRK6

ncbi gi num :

51896037

ncbi acc num :

NP_001004105.1

ncbi gb acc num :

NM_001004105.2

uniprot acc num :

P43250

ncbi mol weight :

64,294 Da

ncbi pathways :

CXCR4-mediated Signaling Events Pathway (137910); Calcium Regulation In The Cardiac Cell Pathway (198906); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Corticotropin-releasing Hormone Pathway (920957); Endocytosis Pathway (102279); Endocytosis Pathway (102181); FSH Signaling Pathway (672455); Morphine Addiction Pathway (552665); Morphine Addiction Pathway (554808)

ncbi summary :

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

GRK6: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Widely expressed. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.7.11.16; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; GRK family; GRK subfamily. Chromosomal Location of Human Ortholog: 5q35. Cellular Component: membrane. Molecular Function: G-protein coupled receptor kinase activity; protein binding; ATP binding. Biological Process: Wnt receptor signaling pathway; protein amino acid phosphorylation; regulation of G-protein coupled receptor protein signaling pathway

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage