Anti-CD62P Antibody | MyBioSource MBS8200361 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CD62P Antibody

catalog :

MBS8200361

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of CD62P expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates.

product information

catalog number :

MBS8200361

products type :

Antibody

products full name :

Anti-CD62P Antibody

products short name :

[CD62P]

products name syn :

[GMRP; GRMP; P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P]

other names :

[P-selectin; P-selectin; P-selectin; selectin P (granule membrane protein 140kDa, antigen CD62); CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD_antigen: CD62P]

products gene name :

[SELP]

other gene names :

[SELP; SELP; CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM; GMRP; GRMP; GMP-140; LECAM3; PADGEM]

uniprot entry name :

LYAM3_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat, Bovine, Rabbit, Sheep

sequence length :

830

specificity :

Recognizes endogenous levels of CD62P protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipping:Blue ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD62P. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to CD62P

ncbi gi num :

157419154

ncbi acc num :

NP_002996.2

ncbi gb acc num :

NM_003005.3

uniprot acc num :

P16109

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Hemostasis Pathway (1269340); IL-3 Signaling Pathway (198881); IL4-mediated Signaling Events Pathway (137933); Malaria Pathway (152665); Malaria Pathway (152657); Platelet Activation, Signaling And Aggregation Pathway (1269350); Platelet Degranulation Pathway (1269367)

ncbi summary :

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

uniprot summary :

SELP: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the selectin/LECAM family. Protein type: Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 1q22-q25. Cellular Component: nucleoplasm; extracellular space; platelet alpha granule membrane; integral to plasma membrane; cytoplasm; plasma membrane; platelet dense granule membrane; external side of plasma membrane. Molecular Function: heparin binding; protein binding; lipopolysaccharide binding; glycoprotein binding; glycosphingolipid binding; calcium-dependent protein binding; sialic acid binding; fucose binding. Biological Process: platelet activation; positive regulation of leukocyte migration; response to lipopolysaccharide; defense response to Gram-negative bacterium; positive regulation of phosphoinositide 3-kinase cascade; heterophilic cell adhesion; leukocyte adhesion; platelet degranulation; regulation of integrin activation; leukocyte tethering or rolling; cell adhesion; blood coagulation; inflammatory response; leukocyte migration. Disease: Ige Responsiveness, Atopic

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage