Amyloid Fibrils (OC) Antibody: Biotin. Rabbit Anti-Human Amyloid Fibrils (OC) Antibody Polyclonal | MyBioSource MBS805797 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Amyloid Fibrils (OC) Antibody: Biotin. Rabbit Anti-Human Amyloid Fibrils (OC) Antibody Polyclonal

catalog :

MBS805797

quantity :

0.1 mL

price :

420 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, enzyme immunoassay, dot blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of Human Abeta42 fibrils and prefibrillar oligomers showing detection of Amyloid Fibrils (OC) protein using Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507). Primary Antibody: Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507) at 1:1000. Courtesy of: Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., et al. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489. doi: 10.1126/science.1079469.

product information

catalog number :

MBS805797

products type :

Antibody

products full name :

Amyloid Fibrils (OC) Antibody: Biotin. Rabbit Anti-Human Amyloid Fibrils (OC) Antibody Polyclonal

products short name :

[Amyloid Fibrils (OC)]

products name syn :

[OC Antibody, Fibrils Antibody, Amyloid Oligomer ars Antibody, All Antibody, Amyloid beta A4 protein Antibody, ABPP Antibody, APPI Antibody, Alzheimer disease amyloid protein Antibody, Cerebral vascular amyloid peptide Antibody, PreA4 Antibody, Protease nexin-II Antibody, APP Antibody, A4 Antibody, AD Antibody]

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

specificity :

Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrililar oligomers or natively folded proteins. Expected to detect in Mouse and Rat based on species homology.A 1:1000 dilution of MBS805797 was sufficient for detection of amyloid fibrils on PVDF membranes using

purity :

Protein A Purified

form :

Protein A Purified

storage stability :

-20 degree C; 1 year + Avoid freeze/thaw cycle. Shipping: Ships with Blue Ice.

tested application :

Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunofluorescence (IF)

app notes :

1:1000 (Dot Blot)

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Western Blot (WB)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

Immunohistochemistry analysis using Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507). Tissue: Alzheimer's Disease brain. Species: Human. Primary Antibody: Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507) at 1:100. Showing no Amyloid Precursor Protein (APP) cross-reactivity (L), but when conducted with monoclonal 6E10 (R) shows considerable APP cross-reactivity. Courtesy of: Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., et al. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489. doi: 10.1126/science.1079469.

image5 heading :

Dot Blot (DB)

image5 description :

Dot blot analysis using Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507). Tissue: Abeta42 fibrils and prefibrillar oligomers. Species: Human. Primary Antibody: Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507) at 1:1000. Courtesy of: Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., et al. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489. doi: 10.1126/science.1079469.

other info1 :

Conjugate: Biotin. Certificate Of Analysis: ransferred fibrils by colorimetric dot blot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

other info2 :

Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide. Immunogen: Fibrils prepared from human Abeta42 peptide. Research Area(s): Neuroscience; Cell Signaling; Cardiovascular System; Blood. Cellular Localization: Membrane

products categories :

Neuroscience

products description :

Background Info: Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrilllar oligomers or natively folded proteins. Scientific Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-beta peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of alpha-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).

products references :

1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.

size1 :

0.1 mL

price1 :

420 USD

more info or order :

MyBioSource product webpage