EPO Rabbit Polyclonal | MyBioSource MBS769047 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

EPO Rabbit Polyclonal

catalog :

MBS769047

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human kidney tissue slide using MBS769047 ( EPO Antibody) at dilution of 1:100

image 2 :

Mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS769047 ( EPO Antibody) at dilution of 1:500

product information

catalog number :

MBS769047

products type :

Antibody

products full name :

EPO Rabbit Polyclonal

products short name :

[EPO]

products name syn :

[EP, EPO, Epoetin, erythropoietin, MVCD2]

other names :

[erythropoietin; Erythropoietin; erythropoietin; erythropoietin; INN: Epoetin]

products gene name :

[EPO]

other gene names :

[EPO; EPO; EP; MVCD2]

uniprot entry name :

EPO_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat. Other species are not tested.

sequence length :

193

specificity :

Please decide specifity by homology.

purity :

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

form :

Liquid

storage stability :

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:200-1:1000. IHC:1:20-1:200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Testing Data

other info1 :

Immunogen: Erythropoietin. Calculated MW: 32 kDa. Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

products description :

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.

ncbi gi num :

62240997

ncbi acc num :

NP_000790.2

ncbi gb acc num :

NM_000799.2

ncbi pathways :

Cellular Response To Hypoxia Pathway (1270415); Cellular Responses To Stress Pathway (1270414); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); EPO Receptor Signaling Pathway (198882); EPO Signaling Pathway (138051); HIF-1 Signaling Pathway (695200); HIF-1-alpha Transcription Factor Network Pathway (138045); HIF-2-alpha Transcription Factor Network Pathway (137956); Hematopoietic Cell Lineage Pathway (83078)

ncbi summary :

uniprot summary :

EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: cell surface; extracellular region; extracellular space. Molecular Function: erythropoietin receptor binding; hormone activity; protein binding; protein kinase activator activity. Biological Process: activation of protein kinase activity; acute-phase response; aging; apoptosis; blood circulation; embryo implantation; erythrocyte differentiation; erythrocyte maturation; hemoglobin biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; peptidyl-serine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of Ras protein signal transduction; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; response to axon injury; response to electrical stimulus; response to estrogen stimulus; response to hyperoxia; response to lipopolysaccharide; response to salt stress; response to testosterone stimulus; response to vitamin A; signal transduction. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage