catalog number :
MBS767852
products full name :
CFHR3 Rabbit Polyclonal
products short name :
[CFHR3]
products name syn :
[CFHL3, CFHR3, complement factor H related 3, DOWN16, FHR 3, FHR3, H factor like protein 3, HLF4]
other names :
[complement factor H-related protein 3 isoform 2; Complement factor H-related protein 3; complement factor H-related protein 3; complement factor H related 3; DOWN16; H factor-like protein 3]
products gene name :
[CFHR3]
other gene names :
[CFHR3; CFHR3; FHR3; HLF4; CFHL3; FHR-3; DOWN16; CFHL3; FHR3; FHR-3]
uniprot entry name :
FHR3_HUMAN
reactivity :
Human; other species are not tested.
specificity :
Please decide specificity by homology.
purity :
>=95% as determined by SDS-PAGE. Immunogen Affinity Purified
form :
Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
storage stability :
Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
app notes :
WB: 1:500-1:3000. IP: 1:200-1:1000. IHC: 1:50-1:500
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Testing Data(TD)
other info1 :
Immunogen: Complement factor H-related 3. Calculated MW: 45 kDa
ncbi acc num :
NP_001160096.1
ncbi gb acc num :
NM_001166624.1
ncbi pathways :
Complement Cascade Pathway (1269241); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Regulation Of Complement Cascade Pathway (1269250)
ncbi summary :
The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
uniprot summary :
CFHR3: Might be involved in complement regulation. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: extracellular space. Disease: Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1; Macular Degeneration, Age-related, 1