antibody

CES2 Rabbit Polyclonal

MBS767848

0.1 mg

265 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

CES2 Rabbit Polyclonal

[CES2]

[CE-2, CES2A1, PCE-2, iCE]

[cocaine esterase isoform 2; Cocaine esterase; cocaine esterase; carboxylesterase 2; Carboxylesterase 2 (EC:3.1.1.1); CE-2; hCE-2; Methylumbelliferyl-acetate deacetylase 2 (EC:3.1.1.56)]

[CES2]

[CES2; CES2; iCE; CE-2; PCE-2; CES2A1; ICE; CE-2; hCE-2]

EST2_HUMAN

Polyclonal

IgG

Rabbit

Human, mouse; other species are not tested.

607

Please decide the specificity by homology

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

Liquid

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) 1:500 - 1:2000. Immunohistochemistry (IHC) 1:50 - 1:200

Immunohistochemistry (IHC)

Testing Data (TD)

Immunogen: Carboxylesterase 2 (intestine, liver). Calculated MW: 62kd. Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.

37622887

NP_932327.1

NM_198061.2

Biological Oxidations Pathway (1270189); Drug Metabolism - Other Enzymes Pathway (83033); Drug Metabolism - Other Enzymes Pathway (428); E2F Transcription Factor Network Pathway (137934); Fluoropyrimidine Activity Pathway (198778); Irinotecan Pathway (198905); Metabolism Pathway (1269956); Phase 1 - Functionalization Of Compounds Pathway (1270190); Phase I, Non P450 Pathway (198854); Retinol Biosynthesis Pathway (545293)

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

CES2: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.1.84; EC 3.1.1.56; EC 3.1.1.1; Hydrolase; Endoplasmic reticulum; Xenobiotic Metabolism - drug metabolism - other enzymes. Chromosomal Location of Human Ortholog: 16q22.1. Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; extracellular space. Molecular Function: methylumbelliferyl-acetate deacetylase activity. Biological Process: catabolic process; xenobiotic metabolic process

0.1 mg

265 USD