catalog number :
MBS767835
products full name :
CEP350-Specific Rabbit Polyclonal
products short name :
[CEP350]
other names :
[centrosome-associated protein 350; Centrosome-associated protein 350; centrosome-associated protein 350; centrosomal protein 350; Centrosome-associated protein of 350 kDa]
products gene name :
[CEP350]
other gene names :
[CEP350; CEP350; GM133; CAP350; CAP350; KIAA0480; Cep350]
uniprot entry name :
CE350_HUMAN
reactivity :
Human, Mouse, Rat
purity :
>=95% as determined by SDS-PAGE. Immunogen Affinity Purified
storage stability :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:1000; IHC: 1:20-1:200
image1 heading :
Immunohistochemistry
image2 heading :
SDS-PAGE
other info1 :
Immunogen: Centrosomal protein 350kDa
ncbi acc num :
NP_055625.4
ncbi gb acc num :
NM_014810.4
ncbi summary :
The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
uniprot summary :
CEP350: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Protein type: Cell cycle regulation; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 1q25.2. Cellular Component: centrosome; cytoplasm; membrane; nucleoplasm; spindle. Molecular Function: microtubule binding; protein binding