CD44 Rabbit Polyclonal | MyBioSource MBS767714 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD44 Rabbit Polyclonal

catalog :

MBS767714

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using MBS767714 ( CD44 Antibody) at dilution of 1:200

image 2 :

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using MBS767714 ( CD44 Antibody) at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

product information

catalog number :

MBS767714

products type :

Antibody

products full name :

CD44 Rabbit Polyclonal

products short name :

[CD44]

products name syn :

[anti-CD44 antibody; LHR, MDU2, MDU3, MIC4]

other names :

[CD44, partial; CD44 antigen; CD44 antigen; CD44 molecule (Indian blood group); CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44]

products gene name :

[CD44]

other gene names :

[CD44; CD44; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I]

uniprot entry name :

CD44_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

specificity :

Human, Mouse; other species are not tested. Please decide the specificity by homology

purity :

Purity: >=95% as determined by SDS-PAGE. Purification: Immunogen Affinity Purified

form :

Liquid

storage stability :

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA, WB, IHC, IP, FC, IF

app notes :

WB : 1:500-1:5000. IP :1:1000-1:10000. IHC : 1:100-1:500. IF : 1:50-1:500

image1 heading :

Immunohistochemistry

image2 heading :

Immunofluorescent

image3 heading :

Western Blot

other info1 :

Immunogen: CD44 molecule (Indian blood group)

products description :

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

ncbi gi num :

685122

ncbi acc num :

AAB30429.1

ncbi mol weight :

80-95 kDa

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (1269373); Cytokine Signaling In Immune System Pathway (1269310); Degradation Of The Extracellular Matrix Pathway (1270257); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Extracellular Matrix Organization Pathway (1270244); Glycosaminoglycan Metabolism Pathway (1269972); Hematopoietic Cell Lineage Pathway (83078)

ncbi summary :

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

uniprot summary :

CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11p13. Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi apparatus; integral to plasma membrane; plasma membrane. Molecular Function: collagen binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; hyaluronic acid binding; hyalurononglucosaminidase activity; protein binding. Biological Process: cartilage development; cell-cell adhesion; cell-matrix adhesion; extracellular matrix disassembly; extracellular matrix organization and biogenesis; hyaluronan catabolic process; leukocyte migration; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of heterotypic cell-cell adhesion; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation. Disease: Blood Group, Indian System

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage