antibody

Cardiac Troponin T Rabbit Polyclonal

MBS767506

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

Cardiac Troponin T Rabbit Polyclonal

[Cardiac Troponin T]

[Cardiac Troponin T, CMH2, cTnT, TNNT2, TnTC]

[cardiac troponin T; Troponin T, cardiac muscle; troponin T, cardiac muscle; troponin T2, cardiac type; Cardiac muscle troponin T; cTnT]

[TNNT2; TNNT2; CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6; TnTc; cTnT]

TNNT2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

288

Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF),

Recommended dilution: . WB : 1:500-1:5000. IHC : 1:20-1:200. IF : 1:50-1:500

Immunohistochemistry (IHC)

Western Blot (WB)

Immunogen: Troponin T type 2 (cardiac). Purification: Immunogen affinity purified. Purity: > 95% as determined by SDS-PAGE

15290516

AAK92231.1

34-40 kDa

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Cardiac Progenitor Differentiation Pathway (712094); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (1269868)

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Protein type: Motor; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: cytosol; sarcomere; striated muscle thin filament; troponin complex. Molecular Function: actin binding; ATPase activity; protein binding; protein binding, bridging; tropomyosin binding; troponin C binding; troponin I binding. Biological Process: actin crosslink formation; cardiac muscle contraction; muscle filament sliding; negative regulation of ATPase activity; positive regulation of ATPase activity; protein heterooligomerization; regulation of heart contraction; regulation of muscle filament sliding speed; response to calcium ion; ventricular cardiac muscle morphogenesis. Disease: Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2; Cardiomyopathy, Familial Restrictive, 3

0.1 mg

290 USD