antibody

Beta-2-microglobulin Rabbit Polyclonal

MBS767113

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry

Antibody

Beta-2-microglobulin Rabbit Polyclonal

[Beta-2-microglobulin]

[B2M]

[beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta-2-microglobulin]

[B2M; B2M; IMD43]

B2MG_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat. Other species are not tested.

119

Please decide specifity by homology.

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

Liquid

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

ELISA, WB, IHC.

WB: 1:500- 1:2000. IHC: 1:50- 1:200

Immunogen: Beta-2-microglobulin. Calculated MW: 12 kDa

Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

4757826

NP_004039.1

NM_004048.2

Adaptive Immune System Pathway (1269171); Amyloid Fiber Formation Pathway (1269169); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (1269194); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (1269195); Class I MHC Mediated Antigen Processing Presentation Pathway (1269192); Cytokine Signaling In Immune System Pathway (1269310); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284)

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: cytoplasm; early endosome membrane; endoplasmic reticulum lumen; external side of plasma membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane. Molecular Function: glycoprotein binding; identical protein binding; protein binding. Biological Process: antibacterial humoral response; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; innate immune response; iron ion homeostasis; positive regulation of protein binding; positive regulation of receptor-mediated endocytosis; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; protein refolding; regulation of defense response to virus by virus; regulation of immune response; response to cadmium ion; response to drug; retinal homeostasis; T cell differentiation in the thymus. Disease: Hypoproteinemia, Hypercatabolic

0.1 mg

290 USD