Autotaxin Rabbit Polyclonal | MyBioSource MBS766981 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Autotaxin Rabbit Polyclonal

catalog :

MBS766981

quantity :

0.1 mg

price :

265 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using MBS766981 (ENPP2 Antibody) at dilution of 1:50)

image 2 :

mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS766981 (ENPP2 antibody) at dilution of 1:500

product information

catalog number :

MBS766981

products type :

Antibody

products full name :

Autotaxin Rabbit Polyclonal

products short name :

[Autotaxin]

products name syn :

[ATX, ATX X, Autotaxin, E NPP 2, ENPP2, FLJ26803, LysoPLD, PD IALPHA, PDNP2]

other names :

[autotaxin; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; ectonucleotide pyrophosphatase/phosphodiesterase 2; Autotaxin; Extracellular lysophospholipase D; LysoPLD]

other gene names :

[ENPP2; ENPP2; ATX; NPP2; ATX-X; PDNP2; LysoPLD; AUTOTAXIN; PD-IALPHA; ATX; PDNP2; E-NPP 2; LysoPLD]

uniprot entry name :

ENPP2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

915

specificity :

Human, Mouse, Rat; other species are not tested. Please decide the specificity by homology

purity :

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

form :

Liquid

storage stability :

-20°C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

app notes :

WB : 1:500-1:1000. IP :1:500-1:1000. IHC : 1:20-1:200

image1 heading :

Immunohistochemistry

image2 heading :

SDS-PAGE

other info1 :

Immunogen: Ectonucleotide pyrophosphatase/phosphodiesterase 2. Calculated MW: 100kd

other info2 :

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3

products description :

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

ncbi gi num :

537906

ncbi acc num :

AAA64785.1

uniprot acc num :

Q13822

ncbi pathways :

Ether Lipid Metabolism Pathway (82990); Ether Lipid Metabolism Pathway (365)

ncbi summary :

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

uniprot summary :

ENPP2: Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; EC 3.1.4.39; Phosphodiesterase; Lipid Metabolism - ether lipid; Secreted. Chromosomal Location of Human Ortholog: 8q24.1. Cellular Component: extracellular space; integral to plasma membrane; plasma membrane. Molecular Function: alkylglycerophosphoethanolamine phosphodiesterase activity; calcium ion binding; hydrolase activity; lysophospholipase activity; nucleic acid binding; nucleotide diphosphatase activity; phosphodiesterase I activity; polysaccharide binding; scavenger receptor activity; transcription factor binding; zinc ion binding. Biological Process: cell motility; chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; phosphate metabolic process; phospholipid catabolic process; positive regulation of peptidyl-tyrosine phosphorylation; receptor-mediated endocytosis; regulation of angiogenesis; regulation of cell migration

size1 :

0.1 mg

price1 :

265 USD

more info or order :

MyBioSource product webpage