ALK, CD246 Mouse Monoclonal | MyBioSource MBS766542 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ALK, CD246 Mouse Monoclonal

catalog :

MBS766542

quantity :

0.1 mg

price :

265 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human lymphoma slide using MBS766542 (ALK, CD246 Antibody)at dilution of 1:50

image 2 :

Recombinant protein were subjected to SDS PAGE followed by Western BLot with MBS766542 (ALK, CD246 Antibody) at dilution of 1:1000

product information

catalog number :

MBS766542

products type :

Antibody

products full name :

ALK, CD246 Mouse Monoclonal

products short name :

[ALK, CD246]

products name syn :

[ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK]

other names :

[ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; anaplastic lymphoma receptor tyrosine kinase; Anaplastic lymphoma kinase; CD_antigen: CD246]

products gene name :

[ALK, CD246]

other gene names :

[ALK; ALK; CD246; NBLST3]

uniprot entry name :

ALK_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

host :

Mouse

reactivity :

Human; other species are not tested.

sequence length :

1620

specificity :

Please decide specifity by homology.

purity :

>=95% as determined by SDS-PAGE. Protein A+G purification

form :

Liquid. PBS with 0.02% Sodium azide and 50% Glycerol pH 7.3

storage stability :

Store at -20°C for 24 months (Avoid repeated freeze/ thaw cycles)

tested application :

ELISA, IHC, WB

app notes :

WB 1:500-1:5000. IHC 1:20-1:200

image1 heading :

Immunohistochemistry IHC

image2 heading :

Testing Data TD

other info1 :

Immunogen: Anaplastic lymphoma receptor tyrosine kinase. Calculated MW: 176 kDa

products description :

ALK, also named as CD246, is a receptor tyrosine kinase(RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM(Nucleophosmin)-ALK oncogenic fusion protein, resulting from the(2;5)(p23;q35)translocation that is frequently associated with anaplastic large-cell lymphoma(ALCL). TheEML4(echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer(NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC(PMID: 17625570).

ncbi gi num :

29029632

ncbi acc num :

NP_004295.2

ncbi gb acc num :

NM_004304.4

ncbi pathways :

Non-small Cell Lung Cancer Pathway (83119); Non-small Cell Lung Cancer Pathway (531)

ncbi summary :

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

uniprot summary :

ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors. Protein type: Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Kinase, protein; Oncoprotein; TK group; Alk family. Chromosomal Location of Human Ortholog: 2p23. Cellular Component: integral to plasma membrane; intracellular; protein complex. Molecular Function: ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity. Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; cell proliferation; neuron development; peptidyl-tyrosine phosphorylation; phosphorylation; protein amino acid autophosphorylation; regulation of apoptosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Neuroblastoma, Susceptibility To, 3

size1 :

0.1 mg

price1 :

265 USD

more info or order :

MyBioSource product webpage