catalog number :
MBS766275
products full name :
ABCG4 Rabbit Polyclonal
products short name :
[ABCG4]
products name syn :
[ABCG4, WHITE2]
other names :
[ATP-binding cassette sub-family G member 4; ATP-binding cassette sub-family G member 4; ATP-binding cassette sub-family G member 4; ATP binding cassette subfamily G member 4]
products gene name :
[ABCG4]
other gene names :
[ABCG4; ABCG4; WHITE2; WHITE2]
uniprot entry name :
ABCG4_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Human, Mouse,Rat; other species are not tested. Please decide the specificity by homology
purity :
>=95% as determined by SDS-PAGE. Immunogen Affinity Purified
storage stability :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB :1:200-1:2000;IHC:1:20-1:200
image1 heading :
Immunohistochemistry
image2 heading :
SDS-PAGE
products description :
Background/Introduction: May be involved in macrophage lipid homeostasis.
ncbi acc num :
NP_001135977.1
ncbi gb acc num :
NM_001142505.1
ncbi pathways :
ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC Transporters In Lipid Homeostasis Pathway (1269905); ABC-family Proteins Mediated Transport Pathway (1269904); Transmembrane Transport Of Small Molecules Pathway (1269903)
ncbi summary :
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
uniprot summary :
ABCG4: May be involved in macrophage lipid homeostasis. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Protein type: Membrane protein, multi-pass; Transporter, ABC family; Transporter; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11q23.3. Cellular Component: integral to membrane; plasma membrane. Molecular Function: ATP binding; cholesterol transporter activity; protein binding; protein heterodimerization activity; protein homodimerization activity; sterol-transporting ATPase activity. Biological Process: cholesterol efflux; metabolic process; transmembrane transport