antibody

URAT1 Rabbit Polyclonal

MBS7605518

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

URAT1 Rabbit Polyclonal

[URAT1]

[OAT4L, OATL4, Renal specific transporter, RST, SLC22A12, URAT1, Urate anion exchanger 1]

[URAT1; Solute carrier family 22 member 12; solute carrier family 22 member 12; solute carrier family 22 member 12; Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1]

[URAT1]

[SLC22A12; SLC22A12; RST; OAT4L; URAT1; OATL4; URAT1; RST]

S22AC_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

553

Purification: Immunogen affinity purified. Purity: > or = 95% as determined by SDS-PAGE

Liquid

-20°C for 24 months (Avoid repeated freeze / thaw cycles.)

ELISA (EIA), Western Blot (WB)

WB : 1:200-1:2000

SDS-PAGE

Immunogen: Solute carrier family 22 (organic anion/urate transporter), member 12 . Calculated MW: 40kDa or 60kDa

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3

Human urate anion exchanger (URAT1), also known as SLC22A12, is a urate transporter located in the proximal tubules of human kidney and responsible for urate reabsorption. Defects in gene encoding URAT1 cause hypouricemia renal type 1 (RHUC1). This antibody recognizes the native and glycosylated URAT1 between 65 and 70 kDa as well as the truncated 40kDa protein.

21239030

BAB96750.1

Q96S37

Organic Anion Transport Pathway (1269938); Organic Cation/anion/zwitterion Transport Pathway (1269936); SLC-mediated Transmembrane Transport Pathway (1269907); Transmembrane Transport Of Small Molecules Pathway (1269903); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (1269923)

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family. Chromosomal Location of Human Ortholog: 11q13.1. Cellular Component: apical plasma membrane; brush border membrane; integral to membrane; integral to plasma membrane; plasma membrane. Molecular Function: inorganic anion exchanger activity; PDZ domain binding; sodium-independent organic anion transmembrane transporter activity; urate transmembrane transporter activity. Biological Process: cellular homeostasis; response to drug; sodium-independent organic anion transport; urate metabolic process; urate transport. Disease: Hypouricemia, Renal, 1

0.1 mg

290 USD