TSG101 Rabbit Polyclonal | MyBioSource MBS7605273 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TSG101 Rabbit Polyclonal

catalog :

MBS7605273

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using MBS7605273 ( TSG101 Antibody)at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

image 2 :

HeLa cells were subjected to SDS PAGE followed by western blot with MBS7605273 (TSG101 antibody) at dilution of 1:1000

product information

catalog number :

MBS7605273

products type :

Antibody

products full name :

TSG101 Rabbit Polyclonal

products short name :

[TSG101]

products name syn :

[ESCRT I complex subunit TSG101, TSG10, TSG101, tumor susceptibility gene 101, VPS23]

other names :

[tumor susceptibility gene 101 protein; Tumor susceptibility gene 101 protein; tumor susceptibility gene 101 protein; tumor susceptibility 101; ESCRT-I complex subunit TSG101]

products gene name :

[TSG101]

other gene names :

[TSG101; TSG101; TSG10; VPS23]

uniprot entry name :

TS101_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse ,Rat; other species are not tested.

sequence length :

390

specificity :

Please decide the specificity by homology

purity :

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

form :

Liquid

storage stability :

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500 - 1:2000. IHC: 1:50 - 1:100

image1 heading :

Immunohistochemistry

image2 heading :

SDS PAGE

other info1 :

Immunogen: Tumor susceptibility gene 101. Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3

other info2 :

Calculated MW: 44 kDa

products description :

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression .

ncbi gi num :

5454140

ncbi acc num :

NP_006283.1

ncbi gb acc num :

NM_006292.3

ncbi pathways :

Assembly Of The HIV Virion Pathway (1269086); Budding And Maturation Of HIV Virion Pathway (1269090); Disease Pathway (1268854); ESCRT-I Complex Pathway (413473); ESCRT-I Complex Pathway (890624); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Endosomal Sorting Complex Required For Transport (ESCRT) Pathway (1269895); Glucocorticoid Receptor Regulatory Network Pathway (138014); HIV Infection Pathway (1269057)

ncbi summary :

uniprot summary :

TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor co-regulator; Cell cycle regulation. Chromosomal Location of Human Ortholog: 11p15. Cellular Component: cytoplasm; early endosome; endosome; endosome membrane; late endosome; late endosome membrane; multivesicular body; nucleolus; plasma membrane. Molecular Function: calcium-dependent protein binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; transcription corepressor activity; ubiquitin binding; ubiquitin protein ligase binding; virion binding. Biological Process: autophagy; cell cycle arrest; cell division; endosome to lysosome transport; endosome transport; keratinocyte differentiation; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; non-lytic virus budding; positive regulation of viral reproduction; protein monoubiquitination; protein transport; regulation of cell growth; regulation of MAP kinase activity; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; viral infectious cycle. Disease: Breast Cancer

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage