antibody

TREM1 Rabbit Polyclonal

MBS7605193

0.1 mg

320 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, flow cytometry, FACS, enzyme immunoassay

Antibody

TREM1 Rabbit Polyclonal

[TREM1]

[CD354,TREM-1,Triggering receptor expressed on monocytes 1]

[triggering receptor expressed on myeloid cells 1 isoform 2; Triggering receptor expressed on myeloid cells 1; triggering receptor expressed on myeloid cells 1; triggering receptor expressed on myeloid cells 1; Triggering receptor expressed on monocytes 1; CD_antigen: CD354]

[TREM1]

[TREM1; TREM1; CD354; TREM-1; TREM-1]

TREM1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse; other species are not tested. Please decide the specificity by homology.

Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3

-20°C for 24 months (Avoid repeated freeze / thaw cycles.)

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Flow Cytometry (FC/FACS)

WB: 1:5000-1:2000. IF: 1:1-10-1:100

Immunofluorescence (IF)

Western Blot (WB)

Purification: Immunogen affinity purified. Purity: >=95% as determined by SDS-PAGE. Immunogen: Triggering receptor expressed on myeloid cells 1

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.

336088680

NP_001229518.1

NM_001242589.2

Q9NP99

30kDa

Adaptive Immune System Pathway (1269171); Cell Surface Interactions At The Vascular Wall Pathway (1269373); DAP12 Interactions Pathway (1269283); Hemostasis Pathway (1269340); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201); Innate Immune System Pathway (1269203)

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

TREM1: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: extracellular region; integral to membrane; intracellular; plasma membrane. Molecular Function: receptor activity. Biological Process: chemokine metabolic process; cytokine secretion during immune response; humoral immune response; innate immune response; leukocyte migration; neutrophil chemotaxis; positive regulation of defense response to virus by host; regulation of immune response

0.1 mg

320 USD