antibody

RNASEH2C Rabbit Polyclonal

MBS7603563

0.1 mg

320 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

Antibody

RNASEH2C Rabbit Polyclonal

[RNASEH2C]

[AGS3, AYP1, Ribonuc ease H2 subunit C, ribonuclease H2, subunit C,Ribonuclease HI subunit C, RNase H1 small subunit, RNase H2 subunit C,RNASEH2C]

[ribonuclease H2 subunit C; Ribonuclease H2 subunit C; ribonuclease H2 subunit C; ribonuclease H2 subunit C; Aicardi-Goutieres syndrome 3 protein; AGS3; RNase H1 small subunit; Ribonuclease HI subunit C]

[RNASEH2C]

[RNASEH2C; RNASEH2C; AGS3; AYP1; AYP1; RNase H2 subunit C; AGS3]

RNH2C_HUMAN

Polyclonal

IgG

Rabbit

Human; other species are not tested.

164

Please decide the specificity by homology

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

Liquid

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

WB: 1:200-1:1000. IHC: 1:20-1:200. IP: 1:500-1:1000

Samples: Urine, Serum, Plasma, Tissue Extracts, Cell Lysate, Cell Culture Media And Other Biological Fluids Samples. Detection Range: 2 umol/L-200 umol/L

Background/Introduction: Nitric oxide (NO) is a reactive radical that plays an important role in many key physiological functions. NO, an oxidation product of arginine by nitric oxide synthase, is involved in host defense and development, activation of regulatory proteins and direct covalent interaction with functional biomolecules. Simple, direct and automation-ready procedures for measuring NO are becoming popular in Research and Drug Discovery. Since NO is oxidized to nitrite and nitrate, it is common practice to quantitate total NO2-/NO3-as a measure for NO level. The reaction products can be measured at a colorimetric readout at 550 nm.

38176285

NP_115569.2

NM_032193.3

DNA Replication Pathway (83039); DNA Replication Pathway (444)

This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]

RNASEH2C: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2C are the cause of Aicardi-Goutieres syndrome type 3 (AGS3). A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Belongs to the RNase H2 subunit C family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA replication. Chromosomal Location of Human Ortholog: 11q13.1. Cellular Component: nucleus. Molecular Function: ribonuclease H activity. Biological Process: RNA catabolic process. Disease: Aicardi-goutieres Syndrome 3

0.1 mg

320 USD