catalog number :
MBS7603345
products full name :
RAP1GDS1 Rabbit Polyclonal
products short name :
[RAP1GDS1]
products name syn :
[Exchange factor smgGDS, GDS1, RAP1GDS1, SMG GDS protein, SmgGDS]
other names :
[rap1 GTPase-GDP dissociation stimulator 1 isoform 6; Rap1 GTPase-GDP dissociation stimulator 1; rap1 GTPase-GDP dissociation stimulator 1; Rap1 GTPase-GDP dissociation stimulator 1; Exchange factor smgGDS; SMG GDS protein; SMG P21 stimulatory GDP/GTP exchange protein]
products gene name :
[RAP1GDS1]
other gene names :
[RAP1GDS1; RAP1GDS1; GDS1; SmgGDS]
uniprot entry name :
GDS1_HUMAN
reactivity :
Human, Mouse; other species are not tested.
specificity :
Please decide the specificity by homology
purity :
>=95% as determined by SDS-PAGE. Immunogen Affinity Purified
storage stability :
Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
app notes :
Western Blot(WB) 1:500-1:1000. Immunoprecipitation (IP) 1:500-1:1000. Immunohistochemistry (IHC) 1:50-1:500
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Testing Data (TD)
other info1 :
Immunogen: RAP1, GTP-GDP dissociation stimulator 1. Calculated MW: 66 kDa. Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3
products description :
Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins(G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.
ncbi acc num :
NP_001093900.1
ncbi gb acc num :
NM_001100430.1
ncbi pathways :
Regulation Of RAC1 Activity Pathway (169346)
ncbi summary :
The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]
uniprot summary :
RAP1GDS1: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. 3 isoforms of the human protein are produced by alternative splicing. Protein type: GEFs, misc.; GEFs. Chromosomal Location of Human Ortholog: 4q23-q25. Cellular Component: cytosol; endoplasmic reticulum; mitochondrion. Molecular Function: GTPase activator activity; protein binding. Biological Process: elevation of mitochondrial calcium ion concentration; positive regulation of GTPase activity; reduction of endoplasmic reticulum calcium ion concentration; small GTPase mediated signal transduction