antibody

Piezo1 Rabbit Polyclonal

MBS7602668

0.1 mg

320 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, enzyme immunoassay

Antibody

Piezo1 Rabbit Polyclonal

[Piezo1]

[FAM38A, KIAA0233]

[piezo-type mechanosensitive ion channel component 1; Piezo-type mechanosensitive ion channel component 1; piezo-type mechanosensitive ion channel component 1; piezo type mechanosensitive ion channel component 1; Membrane protein induced by beta-amyloid treatment; Mib; Protein FAM38A]

[Piezo1]

[PIEZO1; PIEZO1; DHS; Mib; LMPH3; FAM38A; FAM38A; KIAA0233; Mib]

PIEZ1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

2521

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

ELISA (EIA), Western Blot (WB)

WB: 1:200-1:1000

SDS-PAGE

Immunogen: Family with sequence similarity 38, member A

Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).

257196142

NP_001136336.2

NM_001142864.3

The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015]

PIEZO1: Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. Belongs to the PIEZO family. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 16q24.3. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to membrane; plasma membrane. Molecular Function: cation channel activity; mechanically-gated ion channel activity. Biological Process: cation transport; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of integrin activation. Disease: Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/or Perinatal Edema

0.1 mg

320 USD