catalog number :
MBS7602634
products full name :
phospho(409/410)-TDP43 Rabbit Polyclonal
products short name :
[phospho(409/410)-TDP43]
products name syn :
[phospho TDP43, phospho(409/410)-TDP43, TARDBP, TDP43]
products gene name :
[TDP43]
reactivity :
Human, Mouse; other species are not tested.
specificity :
Please decide the specificity by homology.
purity :
>=95% as determined by SDS-PAGE. Immunogen Affinity Purified
form :
Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
storage stability :
-20°C for 24 months (Avoid repeated freeze / thaw cycles.)
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
WB: 1:500-1:2000
image1 heading :
Western Blot
other info1 :
Immunogen: TAR DNA binding protein. Calculated MW: 48 kDa
products description :
TDP-43 is a 414 amino acid (aa) nuclear DNA and RNA-binding protein which regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 25kDa form, in ubiquitin-containing inclusion bodies. Inpathological tissues, TDP-43 is highly phosphorylated and Ser409/410 is the main phosphorylation site. Among the TDP-43 protein fragments, the 25kDa fragment is also highly phosphorylated and widely believed to be pathogenic. This antibody is a rabbit polyclonal antibody recognizing TDP-43 only when phosphorylated at 409/410. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 25 kDa.