catalog number :
MBS7602513
products full name :
PD-L1/CD274 Rabbit Polyclonal
products short name :
[PD-L1/CD274]
products name syn :
[B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274,
Programmed death ligand 1]
products gene name :
[PD-L1/CD274]
reactivity :
Human, Mouse, Rat, other species are not tested.
specificity :
Please decide the specifity by homology.
purity :
>=95% as determined by SDS-PAGE. Immunogen Affinity Purified
form :
Liquid. PBS with 0.02% sodium azide and 50% glycerol pH 7.3
storage stability :
-20°C for 24 months (Avoid repeated freeze / thaw cycles.)
tested application :
ELISA, WB, IHC, IF, IP
app notes :
WB: 1:200-1: 1:1000. IP: 1:500-1:2000. IHC: 1:20-1:200. IF : 1:10-1:100
image1 heading :
Immunohistochemistry
image2 heading :
Immunofluorescent
image3 heading :
SDS-PAGE
other info1 :
Immunogen: CD274 molecule. Calculated MW: 50 kDa, 70 kDa
products description :
Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key
regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation(PMID: 18760278; 16493058).