PDGFD Rabbit Polyclonal | MyBioSource MBS7602498 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PDGFD Rabbit Polyclonal

catalog :

MBS7602498

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemical of paraffin-embedded human prostate cancer using MBS7602498 (PDGFD antibody) at dilution of 1:100

product information

catalog number :

MBS7602498

products type :

Antibody

products full name :

PDGFD Rabbit Polyclonal

products short name :

[PDGFD]

products name syn :

[IEGF, Iris expressed growth factor, MSTP036, PDGF D, PDGFD, PDGFD receptor binding form, SCDGF B, SCDGFB, UNQ1899/PRO4345]

other names :

[platelet-derived growth factor D isoform 2; Platelet-derived growth factor D; platelet-derived growth factor D; platelet derived growth factor D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B]

products gene name :

[PDGFD]

other gene names :

[PDGFD; PDGFD; IEGF; SCDGFB; MSTP036; SCDGF-B; IEGF; SCDGFB; PDGF-D; SCDGF-B; PDGFD latent form; PDGFD receptor-binding form]

uniprot entry name :

PDGFD_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

364

specificity :

Human, Mouse, Rat; other species are not tested. Please decide the specificity by homology

purity :

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

form :

Liquid

storage stability :

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:20-1:200

image1 heading :

Immunohistochemical

other info1 :

Immunogen: Platelet derived growth factor D

products description :

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix(By similarity).

ncbi gi num :

15451921

ncbi acc num :

NP_149126.1

ncbi gb acc num :

NM_033135.3

ncbi mol weight :

43 kDa

ncbi pathways :

Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Gap Junction Pathway (83072); Gap Junction Pathway (483); Melanoma Pathway (83114); Melanoma Pathway (526); PI3K-Akt Signaling Pathway (692234)

ncbi summary :

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

PDGFD: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide; Oncoprotein. Chromosomal Location of Human Ortholog: 11q22.3. Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi membrane. Molecular Function: growth factor activity; platelet-derived growth factor receptor binding. Biological Process: blood coagulation; multicellular organismal development; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fibroblast proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; regulation of peptidyl-tyrosine phosphorylation

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage