catalog number :
MBS7602337
products full name :
PADI2 Rabbit Polyclonal
products short name :
[PADI2]
other names :
[PADI2 protein; Protein-arginine deiminase type-2; protein-arginine deiminase type-2; peptidyl arginine deiminase 2; PAD-H19; Peptidylarginine deiminase II; Protein-arginine deiminase type II]
products gene name :
[PADI2]
other gene names :
[PADI2; PADI2; PAD2; PDI2; PAD-H19; KIAA0994; PAD2; PDI2]
uniprot entry name :
PADI2_HUMAN
reactivity :
Human, Mouse, Rat
purity :
>=95% as determined by SDS-PAGE. Immunogen Affinity Purified
storage stability :
-20°C for 24 months (Avoid repeated freeze / thaw cycles.)
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
other info1 :
Immunogen: Peptidyl arginine deiminase, type II. Calculated MW: 49 kDa, 75 kDa. Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3
ncbi acc num :
AAH09701.1
ncbi pathways :
Chromatin Modifying Enzymes Pathway (1270434); Chromatin Organization Pathway (1270433); Protein Citrullination Pathway (138213)
ncbi summary :
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
uniprot summary :
PADI2: Catalyzes the deimination of arginine residues of proteins. Belongs to the protein arginine deiminase family. Protein type: EC 3.5.3.15; Hydrolase. Chromosomal Location of Human Ortholog: 1p36.13. Cellular Component: cytoplasm; cytosol. Molecular Function: calcium ion binding; estrogen receptor binding; protein-arginine deiminase activity. Biological Process: chromatin-mediated maintenance of transcription; establishment and/or maintenance of chromatin architecture; estrogen receptor signaling pathway; peptidyl-citrulline biosynthetic process from peptidyl-arginine; substantia nigra development