antibody

Myelin basic protein Rabbit Polyclonal

MBS7601698

0.1 mg

265 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry

Antibody

Myelin basic protein Rabbit Polyclonal

[Myelin basic protein]

[MBP, Myelin A1 protein, Myelin basic protein.]

[myelin basic protein; Myelin basic protein; Golli-MBP; myelin basic protein; myelin basic protein; Myelin A1 protein; Myelin membrane encephalitogenic protein]

[MBP; MBP; MBP]

MBP_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat. Other species are not tested.

203

Please decide specifity by homology.

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

Liquid. PBS with 0.02% sodium azide and 50% glycerol pH 7.3

Store at -20°C for 24 months. (Avoid repeated freeze / thaw cycles.)

ELISA, WB, IHC, IF

WB 1:500-1-2000 . IHC 1:50-1:200. IF 1:50-1:200

Immunohistochemistry IHC

Testing Data TD

Immunogen: Myelin basic protein

Calculated MW: 34 kDa

1162922

AAC41944.1

Glial Cell Differentiation Pathway (698758); MAPK Cascade Pathway (198834); Neural Crest Differentiation Pathway (672460); Spinal Cord Injury Pathway (739007)

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

0.1 mg

265 USD