MME, CD10 Mouse Monoclonal | MyBioSource MBS7601465 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MME, CD10 Mouse Monoclonal

catalog :

MBS7601465

quantity :

0.1 mg

price :

265 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemical of paraffin-embedded human renal cell carcinoma using MBS7601465(MME,CDIO antibody) at dilution of 1:100

image 2 :

pig kidney tissue were subjected to SDS-PAGE followed by western blot with MBS7601465 (MME, CD 1 0 Antibody) at dilution of 1:1000

product information

catalog number :

MBS7601465

products type :

Antibody

products full name :

MME, CD10 Mouse Monoclonal

products short name :

[MME, CD10]

products name syn :

[Atriopeptidase, CALLA, CD10, DKFZp686O16152, Enkephalinase, EPN, membrane metallo endopeptidase, MME, NEP, Neprilysin, Neutral endopeptidase, Neutral endopeptidase 24.11]

other names :

[MME protein; Neprilysin; neprilysin; membrane metallo-endopeptidase; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD_antigen: CD10]

products gene name :

[MME, CD10]

other gene names :

[MME; MME; NEP; SFE; CD10; CALLA; EPN; CALLA; NEP; Neutral endopeptidase; SFE]

uniprot entry name :

NEP_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

host :

Mouse

reactivity :

Human, Pig. Other species are not tested.

sequence length :

specificity :

Please decide specifity by homology.

purity :

>=95% as determined by SDS-PAGE. Protein A+G purification

form :

Liquid

storage stability :

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA, WB, IHC

app notes :

WB 1;500-1;5000 . IHC 1;20-1;200

image1 heading :

Immunohistochemistry

image2 heading :

SDS-PAGE

other info1 :

Immunogen: Membrane metallo-endopeptidase. Calculated MW: 86kDa. Observed: 100kDa

other info2 :

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,

products description :

MME is also named as neprilysin,CALLA,NEP,SFE,CD10 and belongs to the peptidase M13 family.It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium.CD10 has been considered a useful marker in the diagnosis of renal carcinomas, because of its expression in clear cell and papillary renal cell carcinomas and its absence in chromophobe renal cell carcinomas(PMID:15286660).This antibody is specific to MME.

ncbi gi num :

76779253

ncbi acc num :

AAI06071.1

ncbi pathways :

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Metabolism Of Angiotensinogen To Angiotensins Pathway (1268749); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868)

ncbi summary :

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

uniprot summary :

CD10: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. Inhibited in a dose dependent manner by opiorphin. Belongs to the peptidase M13 family. Protein type: EC 3.4.24.11; Protease; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q25.2. Cellular Component: axon; brush border; cytoplasm; dendrite; focal adhesion; integral to membrane; integral to plasma membrane; plasma membrane; synapse; synaptic vesicle. Molecular Function: endopeptidase activity; exopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptide binding; protein binding; zinc ion binding. Biological Process: angiotensin maturation; beta-amyloid metabolic process; creatinine metabolic process; kidney development; peptide metabolic process; proteolysis; sensory perception of pain. Disease: Membranous Nephropathy, Susceptibility To

size1 :

0.1 mg

price1 :

265 USD

more info or order :

MyBioSource product webpage