LMP2 Rabbit Polyclonal | MyBioSource MBS7601043 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LMP2 Rabbit Polyclonal

catalog :

MBS7601043

quantity :

0.1 mg

price :

265 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human tonsillitis using MBS7601043 (LMP2 antibody) at dilution of 1:50

image 2 :

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed MCF-7 cells using MBS7601043 (LMP2 antibody) at dilution of 1:50 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L)

image 3 :

Raji cells were subjected to SDS PAGE followed by western blot with MBS7601043 (LMP2 antibody) at dilution of 1:500

product information

catalog number :

MBS7601043

products type :

Antibody

products full name :

LMP2 Rabbit Polyclonal

products short name :

[LMP2]

products name syn :

[20S proteasome, beta1i, LMP2, Low molecular mass protein 2, Macropain chain 7, Proteasome chain 7, Proteasome subunit beta 1i, Proteasome subunit beta type 9, PSMB6i, PSMB9, RING12]

other names :

[LMP2; Proteasome subunit beta type-9; proteasome subunit beta type-9; proteasome subunit beta 9; Low molecular mass protein 2; Macropain chain 7; Multicatalytic endopeptidase complex chain 7; Proteasome chain 7; Proteasome subunit beta-1i; Really interesting new gene 12 protein]

products gene name :

[LMP2]

other gene names :

[PSMB9; PSMB9; LMP2; PSMB6i; RING12; beta1i; LMP2; PSMB6i; RING12]

uniprot entry name :

PSB9_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat.

sequence length :

219

specificity :

Other species are not tested. Please decide the specificity by homology.

purity :

Purification: Immunogen affinity purified. Purity: > = 95% as determined by SDS-PAGE

form :

Liquid. PBS with 0.02% sodium azide and 50% glycerol pH 7.3

storage stability :

-20 degree for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA, Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF).

app notes :

WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

image1 heading :

Immunohistochemistry

image2 heading :

Immunofluorescent

image3 heading :

SDS-PAGE

other info1 :

Immunogen: proteasome(prosome, macropain) subunit, beta type, 9(large multifunctional peptidase 2)

products description :

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.

ncbi gi num :

34635

ncbi acc num :

CAA47024.1

uniprot acc num :

P28065

ncbi mol weight :

21-23 kDa

ncbi pathways :

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (1269838); APC/C:Cdc20 Mediated Degradation Of Securin Pathway (1269849); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (1269844); APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway (1269851); APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway (1269845); ARMS-mediated Activation Pathway (1269471); AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway (1269726); Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (1269842); Activation Of NF-kappaB In B Cells Pathway (1269186); Adaptive Immune System Pathway (1269171)

ncbi summary :

uniprot summary :

PSMB9: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Belongs to the peptidase T1B family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; Proteasome complex; Nuclear receptor co-regulator; EC 3.4.25.1. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: cytoplasm; cytosol; nucleoplasm; proteasome complex; proteasome core complex. Molecular Function: protein binding; threonine endopeptidase activity. Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; liver development; MAPKKK cascade; muscle atrophy; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; response to alkaloid; response to drug; spleen development; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; thymus development; tumor necrosis factor-mediated signaling pathway; viral reproduction; Wnt receptor signaling pathway, planar cell polarity pathway

size1 :

0.1 mg

price1 :

265 USD

more info or order :

MyBioSource product webpage