product summary
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company name :
MyBioSource
product type :
antibody
product name :
LGR6 Rabbit Polyclonal
catalog :
MBS7600999
quantity :
0.1 mg
price :
265 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, flow cytometry, FACS, enzyme immunoassay
more info or order :
image
image 1 :
Immunohistochemistry of paraffin-embedded human testis using MBS7600999 (LGR6 antibody) at dilution of 1:50
image 2 :
1X10^6 HeLa cells were stained with 0.2ug LGR6 antibody (MBS7600999, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.
image 3 :
mouse testis tissue were subjected to SDS PAGE followed by western blot with MBS7600999 (LGR6 antibody) at dilution of 1:100
product information
catalog number :
MBS7600999
products type :
Antibody
products full name :
LGR6 Rabbit Polyclonal
products short name :
[LGR6]
products name syn :
[FLJ14471, GPCR, LGR6, VTS20631]
other names :
[leucine-rich repeat-containing G-protein coupled receptor 6 isoform 3; Leucine-rich repeat-containing G-protein coupled receptor 6; leucine-rich repeat-containing G-protein coupled receptor 6; leucine rich repeat containing G protein-coupled receptor 6]
products gene name :
[LGR6]
other gene names :
[LGR6; LGR6; GPCR; VTS20631]
uniprot entry name :
LGR6_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
828
specificity :
Human, Mouse,Rat; other species are not tested. Please decide the specificity by homology
purity :
>=95% as determined by SDS-PAGE. Immunogen Affinity Purified
form :
Liquid
storage stability :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
tested application :
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB), Flow Cytometry (FC/FACS)
app notes :
WB : 1:200-1:1000. IHC : 1:20-1:200
image1 heading :
Immunohistochemistry
image2 heading :
Flow Cytometry
image3 heading :
SDS-PAGE
other info1 :
Immunogen: leucine-rich repeat-containing G protein-coupled receptor 6
products description :
Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
ncbi gi num :
62912474
ncbi acc num :
NP_001017404.1
ncbi gb acc num :
NM_001017404.1
uniprot acc num :
Q9HBX8
ncbi mol weight :
104 kDa
ncbi pathways :
GPCRs, Other Pathway (198765); Regulation Of FZD By Ubiquitination Pathway (1269607); Signal Transduction Pathway (1269379); Signaling By Wnt Pathway (1269594); TCF Dependent Signaling In Response To WNT Pathway (1269599)
ncbi summary :
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
uniprot summary :
LGR6: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of adult stem cells. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. A marker of a multipotent population of skin stem cells. Three isoforms of the human protein are produced by alternative splicing. Protein type: Tumor suppressor; GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 1q32.1. Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane; vesicle. Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cell migration; positive regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway
size1 :
0.1 mg
price1 :
265 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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