catalog number :
MBS7600458
products full name :
IL-17 Mouse Monoclonal
products short name :
[IL-17]
products name syn :
[CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, interleukin 17A]
products gene name :
[IL-17]
reactivity :
Human; other species are not tested.
specificity :
Please decide the specificity by homology.
purity :
>=95% as determined by SDS-PAGE, Protein A+G purification
form :
Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3
storage stability :
-20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
tested application :
ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
app notes :
WB : 1:500-1:1000
image1 heading :
SDS-PAGE
other info1 :
Immunogen: interleukin 17A
products description :
IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.