IL11RA Rabbit Polyclonal | MyBioSource MBS7600450 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IL11RA Rabbit Polyclonal

catalog :

MBS7600450

quantity :

0.1 mg

price :

265 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, flow cytometry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

1X10^6 K-562 cells were stained with 0.2ug IL11RA antibody (MBS7600450, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.

image 2 :

IF result of anti-IL11RA (MBS7600450, 1:200) with N2a cells (4%PFA fixed) by Miss Masue Marbiah, PhD student MRC Prion Unit, Department of Neurodegenerative Diseases, UCL Institute of Neurology.

image 3 :

mouse heart tissue were subjected to SDS-PAGE followed by Western Blot with MBS7600450 (IL11RA Antibody) at dilution of 1:500

product information

catalog number :

MBS7600450

products type :

Antibody

products full name :

IL11RA Rabbit Polyclonal

products short name :

[IL11RA]

products name syn :

[IL 11 receptor subunit alpha, IL 11R alpha, IL 11R subunit alpha, IL 11RA, IL11RA, interleukin 11 receptor, alpha]

other names :

[interleukin-11 receptor subunit alpha; Interleukin-11 receptor subunit alpha; interleukin-11 receptor subunit alpha; interleukin 11 receptor subunit alpha]

products gene name :

[IL11RA]

other gene names :

[IL11RA; IL11RA; CRSDA; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA]

uniprot entry name :

I11RA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat; other species are not tested.

sequence length :

422

specificity :

Human, Mouse, Rat; other species are not tested. Please decide the specificity by homology

purity :

> 95% as determined by SDS-PAGE; Immunogen affinity purified

form :

Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

storage stability :

Store at -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Flow Cytometry (FC)

app notes :

Recommended dilution: WB: 1:200-1:1000; IF: 1:20-1:200

image1 heading :

Flow Cytometry (FC)

image2 heading :

Immunofluorescence (IF)

image3 heading :

Western Blot (WB)

other info1 :

Immunogen: interleukin 11 receptor, alpha

products description :

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.

ncbi gi num :

218505839

ncbi acc num :

NP_001136256.1

ncbi gb acc num :

NM_001142784.2

uniprot acc num :

Q14626

ncbi mol weight :

45 kDa

ncbi pathways :

Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL-6-type Cytokine Receptor Ligand Interactions Pathway (1339143); Immune System Pathway (1269170); Interleukin-11 Signaling Pathway (698753); Interleukin-6 Family Signaling Pathway (1339142); Jak-STAT Signaling Pathway (83077)

ncbi summary :

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

uniprot summary :

IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 9p13. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity; transmembrane receptor activity. Biological Process: cytokine and chemokine mediated signaling pathway; developmental process; embryo implantation; signal transduction. Disease: Craniosynostosis And Dental Anomalies

size1 :

0.1 mg

price1 :

265 USD

more info or order :

MyBioSource product webpage