IFITM3 Mouse Monoclonal | MyBioSource MBS7600378 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IFITM3 Mouse Monoclonal

catalog :

MBS7600378

quantity :

0.1 mg

price :

320 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human lung cancer using MBS7600378 (IFITM3 antibody) at dilution of 1:50

image 2 :

Immunofluorescent analysis of HepG2 cells, using IFITM3 antibody MBS7600378 at 1:25 dilution and Rhodamine-labeled goat anti-mouse IgG (red).

image 3 :

HeLa cells were subjected to SDS PAGE followed by western blot with MBS7600378 (IFITM3 antibody) at dilution of 1:1000

product information

catalog number :

MBS7600378

products type :

Antibody

products full name :

IFITM3 Mouse Monoclonal

products short name :

[IFITM3]

products name syn :

[1 8U, IFITM3 , IP15]

other names :

[IFITM3; Interferon-induced transmembrane protein 3; interferon-induced transmembrane protein 3; interferon induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U]

products gene name :

[IFITM3]

other gene names :

[IFITM3; IFITM3; 1-8U; IP15; DSPA2b; DSPA2b]

uniprot entry name :

IFM3_HUMAN

clonality :

Monoclonal

isotype :

IgG1

host :

Mouse

reactivity :

Human

sequence length :

133

specificity :

Human; other species are not tested. Please decide the specificity by homology

purity :

>=95% as determined by SDS-PAGE. Protein A+G purification

form :

Liquid

storage stability :

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA, WB, IF, IHC, FC

app notes :

WB : 1:500-1:2000. IHC : 1:20-1:200. IF : 1:10-1:100.

image1 heading :

Immunohistochemistry

image2 heading :

Immunofluorescent

image3 heading :

SDS-PAGE

other info1 :

Immunogen: IFIT2/3 fusion protein. Calculated MW: 14 kDa

products description :

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis.Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell,by letting them go out with a cholesterol depleted membrane.Active against multiple viruses, including influenza A virus, SARS coronavirus(SARS-CoV).Marbug virus(MARV) and Ebola virus(EBOV),Dengue virus(DNV),West Nile virus(WNV),human immunodeficiency virus type 1(HIV-1) and vesicular stomatitis virus (VSV).Can inhibit influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase(v-ATPase).Establiches physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lowew the pH in phagocytic endosomes thus establishing an antiviral state. This antibody recognizes both IFITM2 and IFTIM3.

ncbi gi num :

381148134

ncbi acc num :

AFF60355.1

uniprot acc num :

Q01628

ncbi pathways :

Cytokine Signaling In Immune System Pathway (1269310); Immune System Pathway (1269170); Interferon Signaling Pathway (1269311); Interferon Alpha/beta Signaling Pathway (1269312)

ncbi summary :

The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]

uniprot summary :

IFITM3: IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Interacts with SPP1; the interaction reduces OPN expression. By IFN-alpha and IFNG/IFN-gamma. Belongs to the CD225/Dispanin family. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: integral to membrane; late endosome membrane; lysosomal membrane; plasma membrane. Molecular Function: protein binding. Biological Process: defense response to virus; immune response; negative regulation of viral genome replication; negative regulation of viral transcription; negative regulation of virion penetration into host cell; response to virus. Disease: Influenza, Severe, Susceptibility To

size1 :

0.1 mg

price1 :

320 USD

more info or order :

MyBioSource product webpage