HMGCS1 Rabbit Polyclonal | MyBioSource MBS7600163 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HMGCS1 Rabbit Polyclonal

catalog :

MBS7600163

quantity :

0.1 mg

price :

265 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunofluorescent analysis of HepG2 cells, using HMGCSI antibody MBS7600163 at 1 :25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

image 2 :

IP Result of anti-HMGCSI (IP: HMGCSI antibody, 3ug; Detection: HMGCS 1 antibody 1: 1000) with mouse liver tissue lysate 4000ug.

image 3 :

A431 cells were subjected to SDS PAGE followed by western blot with MBS7600163(HMGCS 1 antibody) at dilution of 1 :500

product information

catalog number :

MBS7600163

products type :

Antibody

products full name :

HMGCS1 Rabbit Polyclonal

products short name :

[HMGCS1]

products name syn :

[HMG CoA synthase, HMGCS, HMGCS1, 3-hydroxy-3-methylglutaryl coenzyme A synthase, Hydroxymethylglutaryl-CoA synthase, cytoplasmic]

other names :

[hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2; Hydroxymethylglutaryl-CoA synthase, cytoplasmic; hydroxymethylglutaryl-CoA synthase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA synthase 1; 3-hydroxy-3-methylglutaryl coenzyme A synthase]

products gene name :

[HMGCS1]

other gene names :

[HMGCS1; HMGCS1; HMGCS; HMGCS; HMG-CoA synthase]

uniprot entry name :

HMCS1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

478

specificity :

Human, Mouse ,Rat; other speCIes are not tested. Please decide the specificity by homology

purity :

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

form :

Liquid

storage stability :

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

app notes :

WB: 1:1000-1:1OOOO. IP: 1:500-1:5000. IF: 1:10-1:100

image1 heading :

Immunofluorescent

image2 heading :

Immunoprecipitation

image3 heading :

Western Blot

other info1 :

Immunogen: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

products description :

HMGCSl(Hydroxymethylglutaryl-CoA synthase, cytoplasmic) is also named as HMGCS and belongs to the HMG-CoA synthase family. The gene encodes a 520 amino acid protein which catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA into 3-hydroxy-3-methylglutaryl CoA and participates in the mevalonate pathway but its end product is cholesterol(PMID:20346956). The human and hamster enzymes are distinguished by differential inhibition by magnesium ion(PMID:2870496).

ncbi gi num :

1023300945

ncbi acc num :

NP_001311152.1

ncbi gb acc num :

NM_001324223.1

ncbi mol weight :

57kDa

ncbi pathways :

Activation Of Gene Expression By SREBF (SREBP) Pathway (1270039); Butanoate Metabolism Pathway (83007); Butanoate Metabolism Pathway (391); C5 Isoprenoid Biosynthesis, Mevalonate Pathway (413387); C5 Isoprenoid Biosynthesis, Mevalonate Pathway (468288); Cholesterol Biosynthesis Pathway (198809); Cholesterol Biosynthesis Pathway (1270037); Endochondral Ossification Pathway (198812); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010)

uniprot summary :

HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family. Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - butanoate. Chromosomal Location of Human Ortholog: 5p14-p13. Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane. Molecular Function: drug binding; hydroxymethylglutaryl-CoA synthase activity; isomerase activity; organic acid binding; protein homodimerization activity. Biological Process: brain development; cholesterol biosynthetic process; isoprenoid biosynthetic process; lipid metabolic process; liver development; male gonad development; response to drug; response to lipoprotein stimulus; response to low light intensity; response to purine; response to tellurium ion; response to vitamin E

size1 :

0.1 mg

price1 :

265 USD

more info or order :

MyBioSource product webpage