HLA class I (HLA-A) Mouse Monoclonal | MyBioSource MBS7600129 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HLA class I (HLA-A) Mouse Monoclonal

catalog :

MBS7600129

quantity :

0.1 mg

price :

320 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using MBS7600129 (HLA class I(HLA-A) Antibody) at dilution of 1:200

image 2 :

HeLa cells were subjected to SDS PAGE followed by western blot with MBS7600129 (HLA class I(HLA-A) Antibody) at dilution of 1:4000

product information

catalog number :

MBS7600129

products type :

Antibody

products full name :

HLA class I (HLA-A) Mouse Monoclonal

products short name :

[HLA class I (HLA-A)]

products name syn :

[HLA A, HLA class I, HLA class I (HLA-A), HLA class I ABC, HLA-A, MHC class I antigen A*3]

other names :

[HLA class I histocompatibility antigen, A-1 alpha chain; HLA class I histocompatibility antigen, A-2 alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; major histocompatibility complex, class I, A; MHC class I antigen A*2]

products gene name :

[HLA-A]

other gene names :

[HLA-A; HLA-A; HLAA; Aw-33; Aw-74; HLA-A11; HLA-A33; HLA-DQB1; HLA-DRB1; HLAA]

uniprot entry name :

1A02_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

host :

Mouse

reactivity :

Human; other species not tested.

sequence length :

365

specificity :

Please decide the specificity by homology

purity :

>=95% as determined by SDS-PAGE. Protein A+G purification

form :

Liquid. PBS with 0.02% sodium azide and 50% glycerol pH 7.3

storage stability :

-20°C for 24 months (Avoid repeated freeze / thaw cycles.)

tested application :

ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

app notes :

WB: 1:1000-1:8000. IHC: 1:20-1:200

image1 heading :

Immunohistochemistry

image2 heading :

SDS-PAGE

other info1 :

Immunogen: Major histocompatibility complex, class I, A. Calculated MW: 44 kDa

ncbi gi num :

24797067

ncbi acc num :

NP_002107.3

ncbi gb acc num :

NM_002116.7

uniprot acc num :

P04439

ncbi pathways :

Adaptive Immune System Pathway (1269171); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (1269194); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (1269195); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533)

ncbi summary :

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

HLAA: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Protein type: Immunoglobulin superfamily; Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum; Golgi apparatus; Golgi medial cisterna; Golgi membrane; integral to plasma membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane. Molecular Function: beta-2-microglobulin binding; peptide antigen binding; protein binding; receptor binding; T cell receptor binding; TAP binding. Biological Process: antibacterial humoral response; antigen processing and presentation; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; defense response to Gram-positive bacterium; detection of bacterium; immune response; positive regulation of interferon-gamma production; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; protection from natural killer cell mediated cytotoxicity; regulation of defense response to virus by virus; regulation of immune response; viral reproduction. Disease: Severe Cutaneous Adverse Reaction, Susceptibility To

size1 :

0.1 mg

price1 :

320 USD

more info or order :

MyBioSource product webpage