catalog number :
MBS754594
products type :
ELISA Kit
products full name :
Rabbit Arsenic (+3 oxidation state) methyltransterase ELISA Kit
products short name :
Arsenic (+3 oxidation state) methyltransterase
other names :
arsenite methyltransferase; Arsenite methyltransferase; arsenite methyltransferase; methyltransferase cyt19; methylarsonite methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase; arsenic (+3 oxidation state) methyltransferase; Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase
products gene name :
AS3MT
other gene names :
AS3MT; AS3MT; CYT19; RP11-753C18.6; CYT19
uniprot entry name :
AS3MT_HUMAN
storage stability :
Store all reagents at 2-8 degree C
products categories :
Metabolism
ncbi acc num :
NP_065733.2
ncbi gb acc num :
NM_020682.3
ncbi mol weight :
41,748 Da
ncbi pathways :
Arsenate Detoxification I (glutaredoxin) Pathway 142442!!Arsenate Detoxification I (glutaredoxin) Pathway 139668
ncbi summary :
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
uniprot summary :
Function: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH . By similarity. Catalytic activity: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate. Subcellular location: Cytoplasm . By similarity. Sequence similarities: Belongs to the methyltransferase superfamily. Biophysicochemical propertiesKinetic parameters:KM=4.6 uM for sodium arsenite Ref.1KM=11.8 uM for AdoMet. Sequence caution: The sequence AAG09731.1 differs from that shown. Reason: Frameshift at position 333.