catalog number :
MBS747279
products type :
ELISA Kit
products full name :
Sheep B cell differentiation factor ELISA Kit
products short name :
B cell differentiation factor
other names :
B cell differentiation factor I; Interleukin-5; interleukin-5; T-cell replacing factor; B-cell differentiation factor I; eosinophil differentiation factor; colony-stimulating factor, eosinophil; interleukin 5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF
products gene name :
BCDE
other gene names :
IL5; IL5; EDF; TRF; IL-5; IL-5; TRF
uniprot entry name :
IL5_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
products categories :
Cell Biology
ncbi acc num :
CAA31211.1
ncbi mol weight :
15,238 Da
ncbi pathways :
Allograft Rejection Pathway 920963!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Asthma Pathway 83120!!Asthma Pathway 532!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Cytokine Signaling In Immune System Pathway 366171!!Cytokine-cytokine Receptor Interaction Pathway 83051
ncbi summary :
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]