ELISA/assay

Human Anti Muscle, Skeletal, receptor tyrosine kinase Antibody ELISA Kit

MBS746658

48-Strip-Wells

470 USD

ELISA Kit

Human Anti Muscle, Skeletal, receptor tyrosine kinase Antibody ELISA Kit

Anti Muscle, Skeletal, receptor tyrosine kinase Antibody

muscle, skeletal, receptor tyrosine kinase; Muscle, skeletal receptor tyrosine-protein kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle localized kinase 2; muscle-specific kinase receptor; muscle-specific protein kinase secretory isoform; muscle-specific tyrosine protein kinase receptor; muscle-specific tyrosine-protein kinase receptor; muscle, skeletal receptor tyrosine protein kinase; muscle, skeletal, receptor tyrosine kinase; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor

MUSK

Musk; Musk; Mlk; Mdk4; Nsk1; Nsk2; Nsk3; Nsk2; MuSK; Muscle-specific kinase receptor

MUSK_MOUSE

Human

Store all reagents at 2-8 degree C.

Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Sensitivity: 0.1 ng/mL.

Intended Uses: This Anti-MUSK ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human Anti-MUSK. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

394933752

BAM29289.1

98,081 Da

ECM Proteoglycans Pathway (1001027); Extracellular Matrix Organization Pathway (1001015)

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity. Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; Kinase, protein; TK group; Musk family. Cellular Component: postsynaptic membrane; cell projection; membrane; integral to plasma membrane; plasma membrane; integral to membrane; synapse; cell junction; neuromuscular junction; receptor complex; external side of plasma membrane. Molecular Function: transferase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; protein kinase binding; ATP binding; protein kinase activity; PDZ domain binding. Biological Process: positive regulation of synaptic transmission, cholinergic; peptidyl-tyrosine phosphorylation; multicellular organismal development; protein amino acid autophosphorylation; positive regulation of synaptic growth at neuromuscular junction; signal transduction; receptor clustering; protein amino acid phosphorylation; memory; positive regulation of peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; regulation of synaptic growth at neuromuscular junction; positive regulation of protein amino acid phosphorylation; cell differentiation; response to electrical stimulus; phosphorylation; neuromuscular junction development

48-Strip-Wells

470 USD

96-Strip-Wells

675