catalog number :
MBS732291
products type :
ELISA Kit
products full name :
Guinea pig Anti-Thrombin III ELISA Kit
products short name :
Anti-Thrombin III
other names :
antithrombin III; Antithrombin-III; antithrombin-III; serpin C1; anti-thrombin 3; serpin peptidase inhibitor, clade C, member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; Serpin C1
products gene name :
AT-III
other gene names :
Serpinc1; Serpinc1; At3; At-3; ATIII; AI114908; At3; ATIII
uniprot entry name :
ANT3_MOUSE
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
AAB23965.1
ncbi mol weight :
52,004 Da
ncbi pathways :
Common Pathway (1001321); Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1001318); Hemostasis Pathway (1001295)
uniprot summary :
SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family. Protein type: Secreted; Secreted, signal peptide; Inhibitor. Cellular Component: extracellular space; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; heparin binding; protease binding; protease inhibitor activity. Biological Process: hemostasis; negative regulation of inflammatory response; negative regulation of peptidase activity; blood coagulation; response to nutrient