Human Bone Morphogenetic Protein 6 ELISA Kit | MyBioSource MBS731443 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Bone Morphogenetic Protein 6 ELISA Kit

catalog :

MBS731443

quantity :

48-Strip-Wells-(Competitive)

price :

440 USD

product information

catalog number :

MBS731443

products type :

ELISA Kit

products full name :

Human Bone Morphogenetic Protein 6 ELISA Kit

products short name :

[Bone Morphogenetic Protein 6]

other names :

[bone morphogenetic protein 6 preproprotein; Bone morphogenetic protein 6; bone morphogenetic protein 6; BMP-6; VGR-1; VG-1-R; VG-1-related protein; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related); bone morphogenetic protein 6; VG-1-related protein; VG-1-R; VGR-1]

products gene name :

[BMP6]

other gene names :

[BMP6; BMP6; VGR; VGR1; VGR; BMP-6; VG-1-R; VGR-1]

uniprot entry name :

BMP6_HUMAN

reactivity :

Human

specificity :

This assay has high sensitivity and excellent specificity for detection of BMP-6. No significant cross-reactivity or interference between BMP-6 and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between BMP-6 and all the analogues, therefore, cross reaction may still exist in some cases.

storage stability :

Store all reagents at 2-8 degree C.

image1 heading :

Typical Standard Curve/Testing Data

other info1 :

Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Assay Type: Competitive or Sandwich. Detection Range: 250-5000pg/mL. Sensitivity: 1.0pg/mL

products categories :

Signal Transduction

products description :

Intended Uses: This BMP-6 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human BMP-6. This ELISA kit for research use only, not for therapeutic or diagnostic applications!. Principle of the Assay: BMP-6 ELISA kit applies the quantitative sandwich enzyme immunoassay technique. The microtiter plate has been pre-coated with a monoclonal antibody specific for BMP-6. Standards or samples are then added to the microtiter plate wells and BMP-6 if present, will bind to the antibody pre-coated wells. In order to quantitatively determine the amount of BMP-6 present in the sample, a standardized preparation of horseradish peroxidase (HRP)-conjugated polyclonal antibody, specific for BMP-6 are added to each well to "sandwich" the BMP-6 immobilized on the plate. The microtiter plate undergoes incubation, and then the wells are thoroughly washed to remove all unbound components. Next, substrate solutions are added to each well. The enzyme (HRP) and substrate are allowed to react over a short incubation period. Only those wells that contain BMP-6 and enzyme-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The BMP-6 concentration in each sample is interpolated from this standard curve.

ncbi gi num :

4502425

ncbi acc num :

NP_001709.1

ncbi gb acc num :

NM_001718.4

ncbi mol weight :

57,226 Da

ncbi pathways :

BMP Receptor Signaling Pathway (137948); Endochondral Ossification Pathway (198812); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Id Signaling Pathway (198871); Ovarian Steroidogenesis Pathway (790011); Ovarian Steroidogenesis Pathway (795173); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475)

ncbi summary :

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

uniprot summary :

BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6p24-p23. Cellular Component: extracellular space; cytoplasm. Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; BMP signaling pathway; regulation of apoptosis; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; inflammatory response; kidney development; response to iron ion; skeletal development; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; positive regulation of protein secretion; eye development; regulation of MAPKKK cascade; cartilage development; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; immune response; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth

size1 :

48-Strip-Wells-(Competitive)

price1 :

440 USD

size2 :

48-Strip-Wells-(Sandwich)

price2 :

440

size3 :

96-Strip-Wells-(Competitive)

price3 :

640

size4 :

96-Strip-Wells-(Sandwich)

price4 :

640

size5 :

5x96-Strip-Wells-(Competitive)

price5 :

2895

size6 :

5x96-Strip-Wells-(Sandwich)

price6 :

2895

size7 :

10x96-Strip-Wells-(Competitive)

price7 :

5415

size8 :

10x96-Strip-Wells-(Sandwich)

price8 :

5415