ELISA/assay

Rat Superoxide Dismutase 2, Mitochondrial ELISA Kit

MBS729914

48-Strip-Wells

470 USD

ELISA Kit

Rat Superoxide Dismutase 2, Mitochondrial ELISA Kit

Superoxide Dismutase 2, Mitochondrial

Superoxide dismutase 2, mitochondrial; Superoxide dismutase [Mn], mitochondrial; superoxide dismutase [Mn], mitochondrial; superoxide dismutase [Mn], mitochondrial; indophenoloxidase B; Mn superoxide dismutase; mangano-superoxide dismutase; manganese-containing superoxide dismutase; superoxide dismutase 2, mitochondrial

SOD2

SOD2; SOD2; IPOB; MNSOD; MVCD6

SODM_HUMAN

Rat

Store all reagents at 2-8 degree C.

Assay Type: Competitive

Highest Standards: 1000pg/mL. Concentration of Standards: Concentration of Standards: 0,50,100,250,500,1000pg/mL

15214595

AAH12423.1

19,730 Da

Cellular Responses To Stress Pathway (645258); DNA Damage Response (only ATM Dependent) Pathway (198827); Detoxification Of Reactive Oxygen Species Pathway (941400); FoxO Family Signaling Pathway (138036); FoxO Signaling Pathway (921162); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Oxidative Stress Pathway (198916); Peroxisome Pathway (131226); Peroxisome Pathway (131126)

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Mitochondrial; Oxidoreductase; EC 1.15.1.1. Chromosomal Location of Human Ortholog: 6q25.3. Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane. Molecular Function: identical protein binding; DNA binding; manganese ion binding; superoxide dismutase activity; oxygen binding. Biological Process: oxygen homeostasis; positive regulation of nitric oxide biosynthetic process; removal of superoxide radicals; heart development; locomotory behavior; response to lipopolysaccharide; response to L-ascorbic acid; post-embryonic development; protein homotetramerization; negative regulation of cell proliferation; response to selenium ion; glutathione metabolic process; acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; regulation of mitochondrial membrane potential; regulation of catalytic activity; regulation of blood pressure; response to gamma radiation; hemopoiesis; response to axon injury; negative regulation of neuron apoptosis; response to electrical stimulus; response to drug; erythrophore differentiation; release of cytochrome c from mitochondria; response to superoxide; superoxide metabolic process; liver development; negative regulation of fat cell differentiation; response to manganese ion; regulation of transcription from RNA polymerase II promoter; iron ion homeostasis; response to silicon dioxide; response to reactive oxygen species; response to cadmium ion; response to hyperoxia; DNA damage response, signal transduction resulting in induction of apoptosis; response to hydrogen peroxide; age-dependent response to reactive oxygen species; response to zinc ion; detection of oxygen; negative regulation of fibroblast proliferation; response to hypoxia; neuron development; response to cold; response to activity; induction of apoptosis by oxidative stress; superoxide release; hydrogen peroxide biosynthetic process. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 6

48-Strip-Wells

470 USD

96-Strip-Wells

675