ELISA/assay

Mouse Oncostatin M Receptor ELISA Kit

MBS729428

48-Strip-Wells

470 USD

ELISA Kit

Mouse Oncostatin M Receptor ELISA Kit

Oncostatin M Receptor

Oncostatin M receptor; Oncostatin-M-specific receptor subunit beta; oncostatin-M-specific receptor subunit beta; IL-31RB; IL-31R-beta; IL-31R subunit beta; IL-31 receptor subunit beta; interleukin-31 receptor subunit beta; oncostatin-M specific receptor beta subunit; oncostatin M receptor; Interleukin-31 receptor subunit beta; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB

OSMR

OSMR; OSMR; OSMRB; PLCA1; OSMRB; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB

OSMR_HUMAN

Mouse

Store all reagents at 2-8 degree C.

Immunology

115529091

AAI25210.1

39,504 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Oncostatin M Signaling Pathway (711361); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979)

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

OSMR: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1); also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 5p13.1. Cellular Component: oncostatin-M receptor complex. Molecular Function: oncostatin-M receptor activity; growth factor binding. Biological Process: positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation. Disease: Amyloidosis, Primary Localized Cutaneous, 1

48-Strip-Wells

470 USD

96-Strip-Wells

675