catalog number :
MBS727695
products type :
ELISA Kit
products full name :
Mouse Forkhead Box Protein O3 ELISA Kit
products short name :
Forkhead Box Protein O3
other names :
forkhead box protein O3; Forkhead box protein O3; forkhead box protein O3; forkhead box O3A; forkhead in rhabdomyosarcoma-like 1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; forkhead box O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1
products gene name :
FOXO3
other gene names :
FOXO3; FOXO3; FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2; FKHRL1; FOXO3A
uniprot entry name :
FOXO3_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
other info1 :
Assay Type: Competitive
other info2 :
Highest Standards: 25ng/mL. Concentration of Standards: Concentration of Standards: 0,1.0,2.5,5.0,10,25ng/mL
products categories :
Signal Transduction
ncbi acc num :
NP_963853.1
ncbi gb acc num :
NM_201559.2
ncbi mol weight :
71,277 Da
ncbi pathways :
AKT Phosphorylates Targets In The Nucleus Pathway (106476); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adaptive Immune System Pathway (366160); BDNF Signaling Pathway (712093); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class I PI3K Signaling Events Pathway (138022); Class I PI3K Signaling Events Mediated By Akt Pathway (138020); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535)
ncbi summary :
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
uniprot summary :
FOXO3A: a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Protein type: DNA-binding; Transcription factor; Oncoprotein; Autophagy. Chromosomal Location of Human Ortholog: 6q21. Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; cytosol. Molecular Function: protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding; transcription factor activity; protein kinase binding. Biological Process: transcription from RNA polymerase II promoter; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; initiation of primordial ovarian follicle growth; positive regulation of erythrocyte differentiation; antral ovarian follicle growth; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; ovulation from ovarian follicle; oocyte maturation; regulation of translation; regulation of transcription from RNA polymerase II promoter; positive regulation of neuron apoptosis; innate immune response; positive regulation of transcription from RNA polymerase II promoter