ELISA/assay

Guinea Pig 17-Alpha Hydroxylase ELISA Kit

MBS727009

96 Strip Wells

675 USD

ELISA Kit

Guinea Pig 17-Alpha Hydroxylase ELISA Kit

17-Alpha Hydroxylase

steroid 17-alpha-hydroxylase/17,20 lyase; Steroid 17-alpha-hydroxylase/17,20 lyase; steroid 17-alpha-hydroxylase/17,20 lyase; CYPXVII; cytochrome P450c17; cytochrome P450-C17; cytochrome P450 17A1; cytochrome p450 XVIIA1; steroid 17-alpha-monooxygenase; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; cytochrome P450, family 17, subfamily A, polypeptide 1; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase

S17AH

CYP17A1; CYP17A1; CPT7; CYP17; S17AH; P450C17; CYP17; S17AH; Cytochrome P450c17

CP17A_HUMAN

Guinea Pig

Store all reagents at 2-8 degree C

Metabolism

4503195

NP_000093.1

NM_000102.3

P05093

57,371 Da

Androgen Biosynthesis Pathway 106154!!Biological Oxidations Pathway 105698!!Cytochrome P450 - Arranged By Substrate Type Pathway 105700!!Endogenous Sterols Pathway 105701!!Glucocorticoid Mineralcorticoid Metabolism Pathway 198902!!Glucocorticoid Biosynthesis Pathway 106152!!Metabolic Pathways 132956!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Metabolism Of Steroid Hormones And Vitamins A And D Pathway 106150!!Phase 1 - Functionalization Of Compounds Pathway 105699

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

Function: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. Catalytic activity: A steroid + AH2 + O2 = a 17-alpha-hydroxysteroid + A + H2O. Cofactor: Heme group. Enzyme regulation: Regulated predominantly by intracellular cAMP levels. Pathway: Lipid metabolism; steroid biosynthesis. Subcellular location: Membrane . Potential. Post-translational modification: Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity. Involvement in disease: Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [. MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic). Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24. Sequence similarities: Belongs to the cytochrome P450 family.

96 Strip Wells

675 USD