catalog number :
MBS726018
products type :
ELISA Kit
products full name :
Rat A Disintegrin And Metalloprotease 9 ELISA Kit
products short name :
A Disintegrin And Metalloprotease 9
other names :
ADAM9 protein; Disintegrin and metalloproteinase domain-containing protein 9; disintegrin and metalloproteinase domain-containing protein 9; cone rod dystrophy 9; myeloma cell metalloproteinase; cellular disintegrin-related protein; ADAM metallopeptidase domain 9 (meltrin gamma); metalloprotease/disintegrin/cysteine-rich protein 9; ADAM metallopeptidase domain 9; Cellular disintegrin-related protein; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase
products gene name :
ADAM9
other gene names :
ADAM9; ADAM9; MCMP; MDC9; CORD9; Mltng; KIAA0021; MCMP; MDC9; MLTNG; ADAM 9
uniprot entry name :
ADAM9_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
products categories :
Cell Biology
ncbi acc num :
AAI26407.1
ncbi mol weight :
72,359 Da
ncbi pathways :
Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262)
ncbi summary :
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
uniprot summary :
ADAM9: Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Protease; Membrane protein, integral. Chromosomal Location of Human Ortholog: 8p11.22. Cellular Component: extracellular space; focal adhesion; cell surface; basolateral plasma membrane; cytoplasm; integral to membrane. Molecular Function: collagen binding; integrin binding; protein binding; protein kinase C binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; laminin binding; SH3 domain binding. Biological Process: positive regulation of keratinocyte migration; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; activation of MAPKK activity; cell-matrix adhesion; membrane protein ectodomain proteolysis; response to glucocorticoid stimulus; positive regulation of cell adhesion mediated by integrin; positive regulation of membrane protein ectodomain proteolysis; keratinocyte differentiation; response to manganese ion; extracellular matrix disassembly; collagen catabolic process; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of protein secretion; response to hydrogen peroxide; monocyte activation; transforming growth factor beta receptor signaling pathway; cell-cell adhesion mediated by integrin; cell adhesion mediated by integrin; cell adhesion; response to calcium ion. Disease: Cone-rod Dystrophy 9