catalog number :
MBS725594
products type :
ELISA Kit
products full name :
Guinea pig Actinin Alpha 2 ELISA Kit
products short name :
Actinin Alpha 2
other names :
alpha-actinin-2 isoform 1; Alpha-actinin-2; alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle; actinin, alpha 2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein
products gene name :
ACTN2
other gene names :
ACTN2; ACTN2; CMD1AA
uniprot entry name :
ACTN2_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
products categories :
Signal Transduction
ncbi acc num :
NP_001094.1
ncbi gb acc num :
NM_001103.3
ncbi mol weight :
103,920 Da
ncbi pathways :
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway 161033!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Arrhythmogenic Right Ventricular Cardiomyopathy Pathway 672454!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117293!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129!!CREB Phosphorylation Through The Activation Of CaMKII Pathway 161040!!CREB Phosphorylation Through The Activation Of Ras Pathway 161036
ncbi summary :
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]