ELISA/assay

Rat Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) ELISA Kit

MBS7253418

48-Strip-Wells

470 USD

ELISA Kit

Rat Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) ELISA Kit

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1)

sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform a; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase

ATP2A1

ATP2A1; ATP2A1; ATP2A; SERCA1; SERCA1; SR Ca(2+)-ATPase 1

AT2A1_HUMAN

Rat

Store all reagents at 2-8 degree C.

Signal Transduction

10835220

NP_004311.1

NM_004320.4

95,199 Da

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Hemostasis Pathway (106028); Ion Channel Transport Pathway (187193); Ion Transport By P-type ATPases Pathway (187194); Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295)

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]

ATP2A1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Associated with sarcolipin (SLN) and phospholamban (PLN). Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression. Skeletal muscle, fast twitch muscle (type II) fibers. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, ion channel; Hydrolase; Transporter; Membrane protein, integral; EC 3.6.3.8; Membrane protein, multi-pass; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 16p12.1. Cellular Component: I band; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; perinuclear region of cytoplasm; integral to membrane; ER-Golgi intermediate compartment. Molecular Function: protein binding; protein homodimerization activity; calcium-transporting ATPase activity; calcium ion binding; ATP binding. Biological Process: apoptotic mitochondrial changes; maintenance of mitochondrion localization; positive regulation of fast-twitch skeletal muscle contraction; metabolic process; calcium ion transport; elevation of endoplasmic reticulum calcium ion concentration; reduction of endoplasmic reticulum calcium ion concentration; regulation of striated muscle contraction; blood coagulation; transmembrane transport; negative regulation of striated muscle contraction; elevation of mitochondrial calcium ion concentration. Disease: Brody Myopathy

48-Strip-Wells

470 USD

96-Strip-Wells

675