ELISA/assay

Human Heme Oxygenase 1, Decycling ELISA Kit

MBS724878

48-Strip-Wells

470 USD

ELISA Kit

Human Heme Oxygenase 1, Decycling ELISA Kit

Heme Oxygenase 1, Decycling

heme oxygenase 1; Heme oxygenase 1; heme oxygenase 1; heme oxygenase (decyclizing) 1; heme oxygenase (decycling) 1; HSP32

HO1

Hmox1; Hmox1; Ho1; Heox; Hmox; Ho-1; HEOXG; hsp32; HO-1

HMOX1_RAT

Human

Store all reagents at 2-8 degree C.

Assay Type: Competitive

Highest Standards: 10ng/mL. Concentration of Standards: Concentration of Standards: 0,0.5,1.0,2.5,5.0,10ng/mL

Neurobiology

6981032

NP_036712.1

NM_012580.2

33,006 Da

HIF-1 Signaling Pathway (695233); Heme Degradation Pathway (1010848); Iron Uptake And Transport Pathway (1010008); Keap1-Nrf2 Pathway (219759); Metabolism Pathway (1010675); Metabolism Of Porphyrins Pathway (1010846); Mineral Absorption Pathway (212234); Mineral Absorption Pathway (212220); NFE2L2 Pathway (739005); Oxidative Stress Pathway (198512)

catalyzes the oxidative cleavage of heme to biliverdin [RGD, Feb 2006]

HMOX1: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. Expressed at higher levels in renal cancer tissue than in normal tissue. Belongs to the heme oxygenase family. Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; EC 1.14.99.3. Cellular Component: endoplasmic reticulum membrane; perinuclear region of cytoplasm; endoplasmic reticulum; plasma membrane; nucleolus; caveola; cytosol; nucleus. Molecular Function: signal transducer activity; protein binding; protein homodimerization activity; enzyme binding; metal ion binding; phospholipase D activity; heme binding; oxidoreductase activity; heme oxygenase (decyclizing) activity. Biological Process: cell death; response to nicotine; negative regulation of smooth muscle cell proliferation; negative regulation of mast cell degranulation; positive regulation of smooth muscle cell proliferation; heme metabolic process; negative regulation of cell proliferation; erythrocyte homeostasis; regulation of transcription factor activity; heme catabolic process; small GTPase mediated signal transduction; regulation of blood pressure; phospholipid metabolic process; negative regulation of mast cell cytokine production; angiogenesis; negative regulation of neuron apoptosis; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; healing during inflammatory response; protein homooligomerization; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription factor activity; heme oxidation; cellular response to nutrient; negative regulation of DNA binding; iron ion homeostasis; positive regulation of angiogenesis; response to hydrogen peroxide; DNA damage response, signal transduction resulting in induction of apoptosis; response to estrogen stimulus; response to hypoxia; response to oxidative stress

48-Strip-Wells

470 USD

96-Strip-Wells

675