ELISA/assay

Mouse Glucose Transporter 1 ELISA Kit

MBS724860

48-Strip-Wells

470 USD

ELISA Kit

Mouse Glucose Transporter 1 ELISA Kit

Glucose Transporter 1

Glut-1, partial; Solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, facilitated glucose transporter member 1; GT1; solute carrier family 2, member 1; glucose transporter type 1, erythrocyte/brain; solute carrier family 2 (facilitated glucose transporter), member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1

GLUT-1

Slc2a1; Slc2a1; Glut1; Glut-1; Glut-1; Glut1; GLUT-1; GT1

GTR1_MOUSE

Mouse

Store all reagents at 2-8 degree C.

Signal Transduction

312593

CAA49367.1

P17809

53,985 Da

Adipocytokine Signaling Pathway (83290); Adipocytokine Signaling Pathway (505); Bile Secretion Pathway (193148); Bile Secretion Pathway (193095); Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (970806); Defective BTD Causes Biotidinase Deficiency Pathway (971178); Defective CD320 Causes Methylmalonic Aciduria Pathway (970626); Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway (970808); Defective GIF Causes Intrinsic Factor Deficiency Pathway (970697); Defective HLCS Causes Multiple Carboxylase Deficiency Pathway (970511)

GLUT1: an integral membrane protein that plays an important role in the glycolytic pathway by serving as a uniporter for glucose. One of 13 members of the human equilibrative glucose transport protein family. Transports a wide range of aldoses, including both pentoses and hexoses, and dehydroascorbic acid. Shown to transport water against an osmotic gradient. A receptor for the Human T-cell Leukemia virus (HTLV). Plays a role in the constitutive or basal uptake of glucose. Expressed at highest levels in proliferating cells of the early developing embryo, cells forming the blood tissue barriers, in human erythrocytes, astrocytes and in cardiac muscle. GLUT1 and GLUT3 are both essential for normal embryonic development. Is practically the only member of the GLUT family expressed on human red blood cells, where it comprises 10 - 20% of the integral membrane protein content. Several glycolytic proteins including the transporters GLUT1 and GLUT3, as well as multiple enzymes including HK2, PFKL, LDHA, ALDOA, ALDOC, PGK1, ENO1, PKM2, CA9 and PFKFB3 are induced in cancer cells by HIF-1 alpha. Polyps from Peutz-Jeghers patients exhibit up-regulated mTORC1 signaling, HIF-1alpha, and GLUT1 levels. Defects in GLUT1 are the cause of autosomal dominant GLUT1 deficiency syndrome, a blood-brain barrier glucose transport defect characterized by infantile seizures, delayed development, and acquired microcephaly. Defects also cause dystonia type 18, an exercise-induced paroxysmal dystonia/dyskinesia. Cytochalasin B binds to its inner surface, inhibiting its glucose transport activity with an IC50 of 0.44 uM. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family. Cellular Component: cortical actin cytoskeleton; integral to plasma membrane; basolateral plasma membrane; integral to membrane; female pronucleus; caveola; intercellular junction; cytosol; lipid raft; membrane; cytoplasm; plasma membrane; intracellular; midbody; vesicle. Molecular Function: identical protein binding; xenobiotic transporter activity; D-glucose transmembrane transporter activity; protein binding; protein self-association; dehydroascorbic acid transporter activity; transporter activity; glucose transmembrane transporter activity; transmembrane transporter activity; kinase binding; substrate-specific transmembrane transporter activity. Biological Process: cellular response to glucose starvation; transport; carbohydrate transport; protein complex assembly; xenobiotic transport; glucose transport; transmembrane transport

48-Strip-Wells

470 USD

96-Strip-Wells

675