ELISA/assay

Human Platelet Derived Growth Factor C ELISA Kit

MBS724441

48-Strip-Wells

470 USD

ELISA Kit

Human Platelet Derived Growth Factor C ELISA Kit

Platelet Derived Growth Factor C

platelet-derived growth factor C; Platelet-derived growth factor C; platelet-derived growth factor C; PDGF-C; VEGF-E; spinal cord-derived growth factor; secretory growth factor-like protein; platelet derived growth factor C; Fallotein; Spinal cord-derived growth factor; SCDGF; VEGF-ECleaved into the following 2 chains:Platelet-derived growth factor C, latent form; PDGFC latent form; Platelet-derived growth factor C, receptor-binding form; PDGFC receptor-binding form

PDGFC

PDGFC; PDGFC; SCDGF; FALLOTEIN; SCDGF; UNQ174/PRO200; PDGF-C; SCDGF; PDGFC latent form; PDGFC receptor-binding form

PDGFC_HUMAN

Human

Store all reagents at 2-8 degree C.

Assay Type: Competitive

Highest Standards: 1000pg/mL. Concentration of Standards: Concentration of Standards: 0,50,100,250,500,1000pg/mL

9994187

NP_057289.1

NM_016205.2

20,609 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Gap Junction Pathway (83072); Gap Junction Pathway (483); Melanoma Pathway (83114); Melanoma Pathway (526); PI3K-Akt Signaling Pathway (692234)

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

PDGFC: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q32. Cellular Component: Golgi membrane; extracellular space; cell surface; endoplasmic reticulum lumen; cytoplasm; plasma membrane; extracellular region; nucleus. Molecular Function: protein binding; protein homodimerization activity; growth factor activity; platelet-derived growth factor receptor binding. Biological Process: positive regulation of fibroblast proliferation; organ morphogenesis; embryonic development; transmembrane receptor protein tyrosine kinase activation (dimerization); central nervous system development; positive regulation of cell division; platelet-derived growth factor receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation; positive regulation of DNA replication

48-Strip-Wells

470 USD

96-Strip-Wells

675