ELISA/assay

Human 11 beta hydroxysteroid dehydrogenase type 1 (11beta HSD1) ELISA Kit

MBS7238715

48-Strip-Wells

470 USD

ELISA Kit

Human 11 beta hydroxysteroid dehydrogenase type 1 (11beta HSD1) ELISA Kit

11 beta hydroxysteroid dehydrogenase type 1 (11beta HSD1)

Human 11 b hydroxysteroid dehydrogenase type 1 (11b HSD1) ELISA Kit

11-beta hydroxysteroid dehydrogenase type 1; Corticosteroid 11-beta-dehydrogenase isozyme 1; corticosteroid 11-beta-dehydrogenase isozyme 1; short chain dehydrogenase/reductase family 26C, member 1; hydroxysteroid (11-beta) dehydrogenase 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1

HSD11B1; HSD11B1; HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1; HSD11; HSD11L; 11-DH; 11-beta-HSD1

DHI1_HUMAN

Human

Store all reagents at 2-8 degree C.

15146338

AAK83653.1

32,401 Da

C21-Steroid Hormone Biosynthesis, Progesterone = Cortisol/cortisone Pathway (413395); C21-Steroid Hormone Biosynthesis, Progesterone = Cortisol/cortisone Pathway (468370); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Glucocorticoid Mineralcorticoid Metabolism Pathway (198902); Glucocorticoid Biosynthesis Pathway (106152); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Steroid Hormones And Vitamin D Pathway (106150)

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]

HSD11B1: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol. Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Belongs to the short-chain dehydrogenases/reductases (SDR) family. Protein type: EC 1.1.1.146; Lipid Metabolism - androgen and estrogen; Lipid Metabolism - C21-steroid hormone; Oxidoreductase; Membrane protein, integral; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 1q32-q41. Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane. Molecular Function: 11-beta-hydroxysteroid dehydrogenase activity. Biological Process: steroid metabolic process; glucocorticoid biosynthetic process; lung development. Disease: Cortisone Reductase Deficiency 2

48-Strip-Wells

470 USD

96-Strip-Wells

675