ELISA/assay

Human Interferon Gamma Inducible Protein 16 ELISA Kit

MBS723779

48-Strip-Wells-(Comp

470 USD

ELISA Kit

Human Interferon Gamma Inducible Protein 16 ELISA Kit

Interferon Gamma Inducible Protein 16

gamma-interferon-inducible protein 16 isoform 1; Gamma-interferon-inducible protein 16; gamma-interferon-inducible protein 16; interferon-gamma induced protein IFI 16; interferon-inducible myeloid differentiation transcriptional activator; interferon, gamma-inducible protein 16; Interferon-inducible myeloid differentiation transcriptional activator

IFI16

IFI16; IFI16; PYHIN2; IFNGIP1; IFNGIP1; Ifi-16

IF16_HUMAN

Human

Store all reagents at 2-8 degree C.

Assay Type: Competitive or Sandwich

Highest Standards: 100pg/mL. Concentration of Standards: Concentration of Standards: 0,5,10,25,50,100pg/mL

Cancer

330864753

NP_001193496.1

NM_001206567.1

82,588 Da

Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); IRF3-mediated Induction Of Type I IFN Pathway (833819); Id Signaling Pathway (198871); Immune System Pathway (106386); Innate Immune System Pathway (106387); STING Mediated Induction Of Host Immune Responses Pathway (685548); Senescence And Autophagy Pathway (198780)

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

IFI16: a nuclear protein that may function as a transcriptional repressor. Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. Binds double-stranded DNA and cell cycle regulatory factors including p53 and Rb. Loss of IFI16 activates p53 checkpoint through NBS1-DNAPK pathway. Inhibits cell growth in the Ras/Raf signaling pathway. May be involved in the senescence of prostate epithelial cells. Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast. Four alternatively spliced isoforms have been described. Isoforms-1, -2 and -3 can homo- and hetero-dimerize. Protein type: Transcription factor. Chromosomal Location of Human Ortholog: 1q22. Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nuclear speck; nucleus; cytosol. Molecular Function: identical protein binding; protein binding; double-stranded DNA binding; transcription factor binding. Biological Process: positive regulation of cytokine production; monocyte differentiation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; negative regulation of DNA binding; positive regulation of interleukin-1 beta production; cellular response to glucose starvation; cell proliferation; negative regulation of viral genome replication; negative regulation of innate immune response; positive regulation of interferon type I production; innate immune response; autophagy; hemopoiesis; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of autophagy; negative regulation of transcription, DNA-dependent; inflammatory response; defense response to virus; activation of innate immune response; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

48-Strip-Wells-(Competitive)

470 USD

48-Strip-Wells-(Sandwich)

470

96-Strip-Wells-(Competitive)

675

96-Strip-Wells-(Sandwich)

675