ELISA/assay

Human 1 phosphatidylinositol 4, 5 bisphosphate phosphodiesterase delta 1 ELISA Kit

MBS7235656

48-Strip-Wells

470 USD

ELISA Kit

Human 1 phosphatidylinositol 4, 5 bisphosphate phosphodiesterase delta 1 ELISA Kit

1 phosphatidylinositol 4, 5 bisphosphate phosphodiesterase delta 1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; PLC-delta-1; phospholipase C-III; phosphoinositide phospholipase C-delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1; phospholipase C, delta 1; Phosphoinositide phospholipase C-delta-1; Phospholipase C-III; PLC-III; Phospholipase C-delta-1; PLC-delta-1

PLCD1

PLCD1; PLCD1; NDNC3; PLC-III; PLC-III; PLC-delta-1

PLCD1_HUMAN

Human

Store all reagents at 2-8 degree C.

Signal Transduction

206729887

P51178.2

88,135 Da

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway (545326); D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway (138940); D-myo-inositol-5-phosphate Metabolism Pathway (545315); D-myo-inositol-5-phosphate Metabolism Pathway (138601); Inositol Phosphate Metabolism Pathway (82987); Inositol Phosphate Metabolism Pathway (730320); Inositol Phosphate Metabolism Pathway (362); Inositol Phosphate Metabolism, PI= PIP2 = Ins(1,4,5)P3 = Ins(1,3,4,5)P4 Pathway (413400)

This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

PLCD1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Defects in PLCD1 are the cause of nail disorder non- syndromic congenital type 3 (NDNC3). NDNC3 is a nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; Phospholipase. Chromosomal Location of Human Ortholog: 3p22-p21.3. Cellular Component: cytoplasm; plasma membrane; cytosol. Molecular Function: signal transducer activity; phosphatidylserine binding; GTPase activating protein binding; calcium ion binding; phosphoinositide phospholipase C activity. Biological Process: inositol phosphate metabolic process; phospholipid metabolic process; angiogenesis; lipid catabolic process; regulation of cell proliferation. Disease: Nail Disorder, Nonsyndromic Congenital, 3

48-Strip-Wells

470 USD

96-Strip-Wells

675